Tetranorditerpene Lactones, Potent Antifungal Antibiotics for Human Pathogenic Yeasts, from a Unique Species of Oidiodendron

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概要

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• The culture filtrate of a fungus isolated from decaying Picea glauca wood and tentatively identified as Oidio-dendron cf. truncatum showed strong antibiotic activity against the pathogenic yeast, Candida albicans. Four new tetranorditerpenoids, oidiodendrolides A (3), B (4), and C (5) and oidiodendronic acid (7) were isolated along with three known tetranorditerpenoids, LL-Z1271α (=PR1387) (1), PR1388 (2), and acrostalidic acid (6), from rice fermented by the above fungus. The structures of oidiodendrolides A (3), B (4), and C (5) and oidiodendronic acid (7) were established on the basis of spectroscopic and chemical investigations. The antifungal activity of the above tetranorditerpenoids against the pathogenic yeasts, Candida albicans and Cryptococcus neoformans is discussed.

• 公益社団法人日本薬学会の論文
• 1999-11-15

著者

• Hosoe Tomoo

  Faculty of Pharmaceutical Sciences, Hoshi University

• Takizawa Kayoko

  Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University

• Kawai Ken-ichi

  Faculty of Pharmaceutical Sciences, Hoshi University

• CURRAH Randolph

  Department of Biological Sciences, University of Alberta

• MIYAJI Makoto

  Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University

• Kawai K

  Hoshi Univ. Tokyo Jpn

• Hosoe Tomoo

  Faculty Of Pharmaceutical Sciences Hoshi University

• Miyaji M

  Research Center For Pathogenic Fungi And Microbial Toxicoses Chiba University

• Miyaji Makoto

  First Department Of Internal Medicine Nagoya City University Medical School

• Miyaji Makoto

  Research Center For Pathogenic Fungi And Microbial Toxicoses Chiba University

• Nozawa K

  School Of Pharmaceutical Sciences Ohu University

• Nozawa Koohei

  Faculty Of Pharmaceutical Sciences Hoshi University

• Currah R

  Univ. Alberta Edmonton Can

• Currah Randolph

  Department Of Biological Sciences University Of Alberta

• Fukushima Kazutaka

  Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University

• Fukushima K

  Research Center For Pathogenic Fungi And Microbial Toxicoses Chiba University

• Fukushima Kazutaka

  Research Center For Pathogenic Fungi And Microbial Toxicoses Chiba University

• Takizawa Kayoko

  Res. Center For Pathogenic Fungi And Microbial Toxicoses Chiba Univ.

• Takizawa Kayoko

  Research Center For Pathogenic Fungi And Microbial Toxicoses Chiba University

• Kawai Koji

  Basic Research Laboratories Toray Industries Inc.

• Kawai Ken-ichi

  Faculty Of Pharmaceutical Sciences

• Takizawa K

  Res. Center For Pathogenic Fungi And Microbial Toxicoses Chiba Univ.

• LUMLEY Trevor

  Department of Biological Sciences, University of Alberta

• Lumley T

  Univ. Alberta Alberta Can

• Lumley Trevor

  Department Of Biological Sciences University Of Alberta

• Tomoo Hosoe

  Faculty Of Pharmaceutical Sciences Hoshi University

• MIYAJI Makoto

  Research Center for Pathogenic Fungi and Microbial Toxicoses

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