C-Terminal Truncation of α-Crystallin in Hereditary Cataractous Rat Lens (Biochemistry/Molecular Biology)

概要

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C-Terminal truncated α-crystallins have been found in lenses of hereditary cataractous rat ICR/f, including two truncated αB-crystallins and several truncated αA-crystallins. These truncated crystallins probably resulted from degradation by m-calpain and Lp82. The αB-crystallin with five amino acid residues deleted showed decreased chaperone activity. Compared with α-crystallins from the normal rat lenses, overall chaperone activity of α-crystallins from the mutant lenses, including the above truncated αB-crystallin, was remarkably reduced. The decreased chaperone activity accompanying the increase in C-terminal truncated α-crystallins may cause the insolubilization of many proteins in the mutant lenses, which it is likely to lead to the progression of cataract formation.
公益社団法人日本薬学会の論文
2004-03-01