Post-translational Modification of αB-Crystallin of Normal Human Lens
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概要
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The current study reports several post-translational modifications of αB-crystallin in normal human lenses. The isoforms of post-translational modified αB-crystallin were isolated from the normal human lenses of >70-age group by ion exchange chromatography and sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The isoform modifications were determined in detail by fast atom bombardment mass spectroscopy and amino acid sequence analysis. As the criterion of non-modified αB-crystallin, αB-crystallin from 1-d-old infant lenses were used. The modifications found in this study involve oxidation of the N-terminal methionine-1 residue, phosphorylation of the serine-59 residue, and truncation of four amino acids from the C-terminal position of the crystallin. The oxidation of methionine-1 was found in the early stage of human life in 1-d-old lens, although other modification of αB-crystallin were usually only found in old lenses (>70-age group).
- 公益社団法人日本薬学会の論文
- 2000-02-01
著者
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MASUDA KATSUYOSHI
Suntory Institute for Bioorganic Research
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KAMEI Akira
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Meijo University
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Masuda K
Showa Pharmaceutical University
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Masuda Katsuyoshi
Suntory Institute For Bioorganic Research Wakayamadai
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Kamei A
Meijo Univ. Aichi Jpn
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Kamei A
Meijo Univ. Nagoya Jpn
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Kamei Akira
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Meijo University
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Masuda K
Shionogi Research Laboratories Shionogi & Co. Ltd.
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Masuda Kouji
Department Of Clinical Radiology Graduate School Of Medical Sciences Kyushu University
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Iwase H
Coky Co. Ltd.
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HAMAGUCHI Takayuki
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Meijo University, Wakayamadai
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MATSUURA Nobuyuki
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Meijo University, Wakayamadai
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IWASE Hiroshi
Coky Co., Ltd.,
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Matsuura N
Meijo Univ. Aichi Jpn
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Matsuura Nobuyuki
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Meijo University
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Hamaguchi Takayuki
Department Of Biochemistry Faculty Of Pharmaceutical Sciences Meijo University Wakayamadai
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Masuda Kouji
Department Of Clinical Radiology Garaduate School Of Medical Sciences Kyushu University
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Kimura Masahiko
Department Of Clinical Radiology Garaduate School Of Medical Sciences Kyushu University
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