Antidiabetic Principles of Natural Medicines. IV. Aldose Reductase and α-Glucosidase Inhibitors from the Roots of Salacia oblonga WALL. (Celastraceae) : Structure of a New Friedelane-Type Triterpene, Kotalagenin 16-Acetate
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概要
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The aqueous methanolic extract of an Indian natural medicine, the roots of Salacia oblonga WALL. (Celastraceae), was found to show inhibitory activity on the increase in serum glucose level in sucrose- and maltose-loaded rats. The water-soluble and ethyl acetate-soluble portions from the aqueous methanolic extract showed inhibitory activities on α-glucosidase and aldose reductase, respectively. From the water-soluble portion, potent α-glucosidase inhibitors, salacinol and kotalanol, were isolated, together with nine sugar related components, while a new friedelane-type triterpene, kotalagenin 16-acetate, was isolated from the ethyl acetate-soluble portion along with known diterpenes and triterpenes. The structure of kotalagenin 16-acetate was elucidated on the basis of physicochemical evidence. Principal components from this natural medicine were examined in terms of inhibitory activity on aldose reductase, and the diterpene and triterpene constituents, including the new kotalagenin 16-acetate, were found to be responsible components for the inhibitory activity on aldose reductase.
- 公益社団法人日本薬学会の論文
- 1999-12-15
著者
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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村上 孝之
Taiho Pharmaceutical Co. Ltd.
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KATO Yasuyo
Kyoto Pharmaceutical University
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MURAKAMI Toshiyuki
Kyoto Pharmaceutical University
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YASHIRO Kenichi
Kyoto Pharmaceutical University
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YAMAHARA Johji
Kyoto Pharmaceutical University
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Yamahara J
Kyoto Pharmaceutical University
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Yamazaki M
School Of Pharmaceutical Sciences Kinki University
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YAMAHARA JOHJI
Kyoto College of Pharmacy
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MATSUDA HISASHI
Kyoto College of Pharmacy
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Murakami Toshiyuki
Kyoto Institute of Technology
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