Effects of Glucosyl Hesperidin on Serum Lipids in Hyperlipidemic Subjects : Preferential Reduction in Elevated Serum Triglyceride Level
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概要
- 論文の詳細を見る
Although hesperidin lowers serum total cholesterol (TC) or triglyceride (TG) in animal models, its effect in humans remains unclear. Using a soluble hesperidin derivative, glucosyl hesperidin (G-hesperidin), as a hesperidin source, we examined the efficacy on hyperlipidemic subjects. G-Hesperidin was administered to the subjects at 100 or 500 mg/d for 6 wk. The percentage of subjects who had a change in serum cholesterol levels was less than 20%. However, 45-55% of the total subjects showed a reduction in serum TG level. The subjects were classified into normal (TC<230mg/dL, TG<150mg/dL), high-TC (TC>230 mg/dL, TG<150 mg/dL) and high-TG (TG>150 mg/dL) types. While serum cholesterol levels scarcely changed in any phenotype, TG level was significantly reduced by administration in the high-TG type. In this phenotype, serum apolipoprotein (apo) C-II and E levels decreased by the administration, but non-apo B. G-Hesperidin also raised low-density lipoprotein (LDL)-cholesterol/apo B in the high-TG type. These results indicate that G-hesperidin preferentially lowers serum TG in hypertriglyceridemic subjects and that this effect is possibly caused by the facilitation of catabolism of TG-rich lipoproteins and may contribute to the reduction of small dense LDL.
- 日本ビタミン学会の論文
著者
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Chaen Hiroto
Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.
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Chaen Hiroto
Glycoscience Institute Hayashibara Biochemical Laboratories Inc.
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Chaen H
Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.
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Kohguchi Michihiro
Fujisaki Institute Hayashibara Biochemical Laboratories Inc.
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Kurimoto M
Amase Institute Hayashibara Biochemical Laboratories Inc.
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Kibata Masayoshi
Hayashibara Biochemical Laboratories Inc.
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YAMADA Mika
Hayashibara Biochemical Laboratories, Inc.
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MITSUZUMI Hitoshi
Hayashibara Biochemical Laboratories, Inc.
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SUNAYAMA Takahiro
Dai-ichi Central Bldg.
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MIWA Yoshikatsu
Research and Development Center, Hayashibara Biochemical Laboratories, Inc.
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YAMADA Mika
Research and Development Center, Hayashibara Biochemical Laboratories, Inc.
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MITSUZUMI Hitoshi
Research and Development Center, Hayashibara Biochemical Laboratories, Inc.
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TSUZAKI Yukari
Research and Development Center, Hayashibara Biochemical Laboratories, Inc.
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CHAEN Hiroto
Research and Development Center, Hayashibara Biochemical Laboratories, Inc.
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MISHIMA Yasuo
Division of Internal Medicine, National Minami Okayama Hospital
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KIBATA Masayoshi
Research and Development Center, Hayashibara Biochemical Laboratories, Inc.
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Mitsuzumi Hitoshi
Hayashibara Biochemical Laboratories Inc.
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Chaen Hiroto
Glycoscience Inst. Res. Center Hayashibara Biochemical Laboratories Inc.
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Yamada Mika
Hayashibara Biochemical Laboratories Inc.
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Kubota Michio
Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.
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Kurose Mayumi
Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.
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Mishima Yasuo
Division Of Internal Medicine National Minami Okayama Hospital
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Mukai Kazuhisa
Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.
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Tsuzaki Yukari
Research And Development Center Hayashibara Biochemical Laboratories Inc.
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Kubota M
Hayashibara Biochemical Laboratories Inc.
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Kubota M
Division Of Applied Bioscience Graduate School Of Agriculture Hokkaido University
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Kurimoto M
Fujisaki Institute Hayashibam Biochemical Laboratories Inc.
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Maruta K
Glycoscience Institute Research Center Hayashibara Biochemical Laboratories Inc.
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Chaen Hiroto
Glycoscience Institute, Research Center, Hayashibara Biochemical Laboratories, Inc.
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