Cytoprotective Effects of 4,6-Bis(1H-pyrazol-1-yl)pyrimidine and Related Compounds on HCl・Ethanol-Induced Gastric Lesions in Rats
スポンサーリンク
概要
- 論文の詳細を見る
Bis(1H-pyrazol-1-yl)- and bis(1H-imidazol-1-yl)pyrimidines were synthesized and evaluated for cytoprotective effects. Among them, 4,6-bis(1H-pyrazol-1-yl)pyrimidine (3) showed a potent inhibitory effect on the HCl・ethanol-, ethanol-, and water immersion stress-induced gastric lesions in rats, and a very low acute toxicity. One of the major factors reponsible for the cytoprotective effects of 3 is the increase in the bicarbonate secretion. This compound appears to be a promising cytoprotective drug for the treatment of gastric mucosal ulcers.
- 公益社団法人日本薬学会の論文
- 1997-03-15
著者
-
Maruyama K
帝京大学 薬 薬剤
-
YAMADA Tatsuhiko
Pharmaceutical Laboratories, Kissei Pharmaceutical Co., Ltd.,
-
IKEDA Masazumi
Kyoto Pharmaceutical University
-
Yamada T
Department Of Radiopharmacy Tohoku Pharmaceutical University
-
Okabe S
Kyoto Pharmaceutical Univ. Kyoto Jpn
-
Ikeda M
Kyoto Pharmaceutical Univ. Kyoto Jpn
-
MARUYAMA Kazumi
Kyoto Pharmaceutical University
-
NOBUHARA Youichi
Nissin Food Products Co., Ltd.,
-
YAMADA Toshihiro
Nissin Food Products Co., Ltd.,
-
OKABE Susumu
Kyoto Pharmaceutical University
-
Nobuhara Yoichi
Central Research Institute Nissin Food Products Co. Ltd.
-
Yamada Takehisa
Research And Development Division Hokuriku Seiyaku Co. Ltd.
-
桐山 美由紀
Meiji Pharmaceutical Univ. Tokyo Jpn
-
Nobuhara Youichi
Central Research Institute Nissin Food Products Co. Ltd.
-
Maruyama K
Kyoto Pharmaceutical University
関連論文
- 酸化防止剤含有ポリエチレン, ポリプロピレン及びポリスチレンに対するガンマ線照射の影響
- 乳幼児用軟質ポリ塩化ビニル製玩具からのフタル酸エステル暴露量の推定
- ポリ塩化ビニル製玩具中の可塑剤フタル酸エステルの分析 : 1998年以降の市販品含有量調査
- 食品用シリコーンゴム製品中の残存化学物質
- 食品用天然ゴム製品中の残存化学物質
- ポリ塩化ビニル製玩具中のフタル酸エステル含有量
- 飲料缶からのビスフェノールA移行原因の解明と改良缶の評価
- ポリ塩化ビニル製手袋中の可塑剤及びノニルフェノールの溶出
- 食品用ポリエチレン, ポリプロピレン及びポリスチレン製品へのガンマ線照射の影響 : 揮発性物質
- 食品用ポリエチレン, ポリプロピレン及びポリスチレン製品へのガンマ線照射の影響 : 添加剤及びその他の化合物
- ガスクロマトグラフィー/原子発光検出法(GC/AED)による食品用器具・容器包装及び玩具中の有機スズ化合物の分析
- 食品用プラスチック製品及び玩具中のノニルフェノール
- 食品用ポリプロピレン製品中の添加剤の分析
- エビ中のコウジ酸の残存量に対する調理等の影響
- 天然着色料中のアスタキサンチンの光学異性及びファフィア色素の主色素成分に関する研究
- Relationship between Liver Injury and Transglutaminase Activities in Guinea Pigs and Rats(Pharmacology)
- Activity of Amphipathic Polyethyleneglycols to Prolong the Circulation Time of Liposomes
- Estimation of Surface State of Poly(ethylene glycol)-Coated Liposomes Using an Aqueous Two-Phase Partitioning Technique
- Preparation of Thermosensitive Liposomes Containing Amphipathic Polyethyleneglycol for Macromolecule Delivery
- Prolongation of Liposome Circulation Time by Various Derivatives of Polyethyleneglycols
- Preparation of Thermosensitive Liposomes for Macromolecule Delivery
- CHARACTERIZATION AND APPLICATION OF POLYETHYLENEGLYCOL-LIPOSOMES
- 2-(3-Pyridyl)thiazolidine-4-carboxamide Derivatives. II. Structure-Activity Relationships and Active Configuration of 2-(3-Pyridyl)thiazolidine-4-carboxamides as Platelet-Activating Factor Receptor Antagonists
- 2-(3-Pyridyl)thiazolidine-4-carboxamides. 1. Novel Orally Active Antagonists of Platelet-Activating Factor (PAF)
- Immuno-potentiating Effects of the Antler-shaped Fruiting Body of Ganoderma lucidum (Rokkaku-Reishi)
- Lumin, a Cyanine Dye, Enhances Interleukin 12-Dependent Interferon Gamma Production by Lipopolysaccharide-Stimulated Mouse Splenocytes
- Effect of Royal Jelly Diet on the Testicular Function of Hamsters
- Identification of a Collagen Production-promoting Factor from an Extract of Royal Jelly and Its Possible Mechanism
- Royal Jelly Inhibits the Production of Proinflammatory Cytokines by Activated Macrophages
- Promoting Effect of Kaempferol on the Differentiation and Mineralization of Murine Pre-osteoblastic Cell Line MC3T3-E1(Food & Nutrition Science)
- Tryptanthrin Inhibits Interferon-γ Production by Peyer's Patch Lymphocytes Derived from Mice That Had Been Orally Administered Staphylococcal Enterotoxin
- Preventive Effect of Coriandrum sativum (Chinese Parsley) on Aluminum Deposition in ICR Mice
- Trehalose Ingestion Modifies Mucosal Immune Responses of the Small Intestine in Mice
- Cell differentiation and apoptosis of monocytic and promyelocytic leukemia cells (U-937 and HL-60) by tryptanthrin, an active ingredient of Polygonum tinctorium Lour
- Antibacterial action of tryptanthrin and kaempferol, isolated from the indigo plant (Polygonum tinctorium Lour.), against Helicobacter pylori-infected Mongolian gerbils
- Renal carcinogenesis induced by ferric nitrilotriacetate in mice, and protection from it by Brazilian propolis and Artepillin C
- Isolation and Identification of Compounds from Brazilian Propolis which Enhance Macrophage Spreading and Mobility
- 酵素分解ハトムギ抽出物の主要成分の分析
- Two New Alkaloids from Cigarette Smoke Condensate
- Calcium Polycarbophil, a Water Absorbing Polymer, Increases Bowel Movement and Prevents Sennoside-Induced Diarrhea in Dogs
- Can Nasal Continuous Positive Airway Pressure Decrease Clinic Blood Pressure in Patients with Obstructive Sleep Apnea?
- Effects of Nasal Continuous Positive Airway Pressure on Awake Ventilatory Responses to Hypoxia and Hypercapnia in Patients with Obstructive Sleep Apnea
- Influence of Sustained Hypoxia on the Sensation of Dyspnea
- Decalcification of Calcium Polycarbophil in Rats
- Sensitive analytical method for the novel H_1-receptor antagonist HSR-609 in human plasma and urine by high-performance liquid chromatography with pre-column fluorescent derivatization
- Effect of Polycarbophil on the Absorption of Nutrients
- 遺伝子組換え顆粒球コロニー形成刺激因子(rhG-CSF)のDDS : 粘膜吸収製剤としての前臨床評価
- Application of Gel Formation for Taste Masking
- ABSORPTION OF RECOMBINANT HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR (rhG-CSP) AND BLOOD LEUKOCYTE DYNAMICS FOLLOWING INTRANASAL ADMINISTRATION IN RABBITS
- A Formal Total Synthesis of (-)-Cephalotaxine
- Approaches to the Cephalotaxine Skeleton Using an Intramolecular Heck Reaction
- NEW COMPRESSED TABLET RAPIDLY DISINTEGRATING IN SALIVA IN THE MOUTH USING CRYSTALLINE CELLULOSE AND A DISINTEGRANT
- Activation of Protein Kinase C by Mycobacterial Cord Factor, Trehalose 6-Monomycolate, Resulting in Tumor Necrosis Factor-α Release in Mouse Lung Tissues
- Dirhodium(II)-Catalyzed Intramolecular Carbon-Hydrogen Insertion Reaction of α-Diazoketones : Synthesis of 7-Silyloxyoctahydrobenzo[b]furan-2-ones
- In Vivo Pharmacologic Profile of YM158, a New Dual Antagonist for Leukotriene D_4 and Thromboxane A_2 Receptors
- Effect of YM158, a Dual Lipid Mediator Antagonist, on Immediate and Late Asthmatic Responses, and on Airway Hyper-responsiveness in Guinea Pigs
- Protective Effect of a Pancreatic Elastase Inhibitor Against a Variety of Acute Pancreatitis in Rats
- Pancreatic Enzyme-Induced Pancreatitis and Systemic Complications in Rats
- Asymmetric Synthesis of (R)-Nilvadipine and (S)-NB 818 via Regioselective Bromination of Chiral 1,4-Dihydropyridines as a Key Step and Enzymatic Resolution of Racemic 2-Hydroxymethyl-1,4-dihydropyridine Derivatives
- Lipase-Catalyzed Enantioselective Hydrolysis of Bis(acyloxymethyl) 1,4-Dihydro-3,5-pyridinedicarboxylates Leading to Optically Active Medicines
- Cytoprotective Effects of 4,6-Bis(1H-pyrazol-1-yl)pyrimidine and Related Compounds on HCl・Ethanol-Induced Gastric Lesions in Rats
- Synthesis and Cytoprotective Antiulcer Activity of 2- or 4-(1H-Pyrazol-1-yl)pyrimidine Derivatives Related to Mepirizole and Dulcerozine
- Effects of NTE-122, an Acyl-CoA : Cholesterol Acyltransferase Inhibitor, on Cholesterol Esterification and Lipid Secretion From CaCo-2 Cells, and Cholesterol Absorption in Rats
- Effects of NTE-122, a Novel Acyl-CoA:Cholesterol Acyltransferase Inhibitor, on Cholesterol Esterification and High-Density Lipoprotein-Induced Cholesterol Efflux in Macrophages
- Effects of NTE-122, a Novel Acyl-CoA:Cholesterol Acyltransferase Inhibitor, on Cholesterol Esterification and Secretions of Apolipoprotein B-Containing Lipoprotein and Bile Acids in HepG2
- Cholesterol : Lowering Effects of NTE : 122, a Novel Acyl : CoA:Cholesterol Acyltransferase (ACAT) Inhibitor, on Cholesterol Diet : Fed Rats and Rabbits
- YM-40461 Improves Airway Clearance in Guinea Pigs with Induced Subacute Bronchitis
- Inclusion Complex of 3,9-Bis(N, N-dimethylcarbamoyloxy)-5H-benzofuro[3,2-c]quinoline-6-one (KCA-098) with Heptakis(2,6-di-O-methyl)-β-cyclodextrin : Interaction and Dissolution Properties
- YM-40461, a Potent Surfactant Secretagogue, Improves Mucocilliary Clearance in SO_2-Exposed Guinea Pigs
- Effect of Grinding with Hydroxypropyl Cellulose on the Dissolution and Particle Size of a Poorly Water-Soluble Drug
- 2-(3-Pyridyl)thiazolidine-4-carboxamide Derivatives. III. Synthesis of Metabolites and Metabolism of 2-(3-Pyridyl)thiazolidine-4-carboxamides YM461 and YM264 as Platelet-Activating Factor (PAF) Receptor Antagonists
- Disaccharide Esters Screened for Inhibition of Tumor Necrosis Factor-α Release Are New Anti-cancer Agents
- Mechanisms of Growth Inhibition of Human Lung Cancer Cell Line, PC-9, by Tea Polyphenols
- New TNF-α Releasing Inhibitors, Geraniin and Corilagin, in Leaves of Acer nikoense, Megusurino-ki
- Modulation of Gene Expression by(-)-Epigallocatechin Gallate in PC-9 Cells Using a cDNA Expression Array
- Mechanistic Aspects of Green Tea as a Cancer Preventive : Effect of Components on Human Stomach Cancer Cell Lines
- Twist Form of Teleocidin Derivatives is Active in in Vivo Tumor Promotion by (-)-Benzolactam-V8-310
- Anti-tumor Promoting Activity of Canventol and Its Synthetic Analogs through Inhibition of Protein Isoprenylation
- Purification and Characterization of a Membrane-bound ATPase from Acetabularia clifeonii That Corresponds to a Cl^- -Translocating ATPase in Acetabularia acetabulum
- Chloroplast ATPase in A cetabularia acetabulum : Purification and Characterization of Chloroplast F_1-ATPase
- Increase in Total Blood Leukocyte Count Following Intranasal Administration of Recombinant Human Granulocyte Colony-Stimulating Factor (rhG-CSF) in Rabbits with Cyclophosphamide-Induced Leukopenia
- Isolation and Identification of New Antifungal Macrophorins E, F and G as Malonyl Meroterpenes from Botryosphaeria berengeriana
- NTE-122, an Acyl-CoA:Cholesterol Acyltransferase Inhibitor, Prevents the Progression of Atherogenesis in Cholesterol-Fed Rabbits
- PB55 SYNTHESIS OF SOME INSECT SEX PHEROMONES BY USING "ENE" REACTION OF α-THIOCARBOCATIONS
- CHARACTERISTICS OF MILD IRRITANTS AND ADAPTIVE CYTOPROTECTION ; ROLE OF ENDOGENOUS PROSTAGLANDINS IN SELF-DEFENSIVE MECHANISMS
- CHANGES IN TRANSMUCOSAL POTENTIAL DIFFERENCE AND LUMINAL PH IN ANESTHETIZED RAT STOMACH AFTER EXPOSURE TO ETHANOL
- Structural Confirmation of Cotylenin A, a Novel Fusicoccane-diterpene Glycoside with Potent Plant Growth-regulating Activity from Cladosporium Fungus sp. 501-7W
- Diastereoselective synthesis of 2-alkylated 4-silyloxyprolineesters
- Control of Chemoselectivity in Dirhodium(II)-Catalyzed Reaction of 5,6-Dioxygenated 2-Diazo-3-oxohexanoates : C-H Insertion Reaction versus Oxonium Ylide Formation
- Asymmetric Synthesis of β-Hydroxy Acid via Stereoselective Dirhodium (II)-Catalyzed C-H Insertion of α-Alkoxydiazoketone
- Direct Temperature Measurement of Melts in Continuous Copper Converter with Expendable Immersion Optical Fiber Thermometer
- Synthesis of Octahydrobenzo[b]furans Using Tandem Conjugate Addition Reactions Initiated by Oxygen Nucleophile
- PB59 A SHORT SYNTHESIS OF (±)-CUPARENE
- ORGANIC SYNTHESIS IN A COLUMN : C-ALKYLATION OF INDOLES AND PYRROLES IN THE PRESENCE OF ALUMINA
- Antiviral Effect of Polygonum tinctorium Lour. Extracts on Virus-Infected Cells
- Preventive Effect of Coriandrum sativum (Chinese Parsley) on Aluminum Deposition in ICR Mice