NTE-122, an Acyl-CoA:Cholesterol Acyltransferase Inhibitor, Prevents the Progression of Atherogenesis in Cholesterol-Fed Rabbits
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概要
- 論文の詳細を見る
The cholesterol-lowering and anti-atherosclerotic effects of NTE-122 (trans-1,4-bis[[1-cyclohexyl-3-(4-dimethylaminophenyl)ureido]methyl]cyclohexane), an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, were evaluated in 1% cholesterol diet-fed rabbits. NTE-122 (1, 3 and 10 mg/kg per day) lowered the total cholesterol levels in both plasma and liver dose-dependently (by 99% and 94% at 10 mg/kg per day, respectively). In the aortic wall of the rabbits given NTE-122, the atherosclerotic lesion area in both aortic arch and thoracic aorta were dose-dependently reduced (by 100% at 10 mg/kg per day), and the total cholesterol content in aortic arch was also lowered significantly at more than 3 mg/kg per day. These results suggest that NTE-122 is capable of exhibiting anti-atherosclerotic effects.
- 社団法人 日本薬理学会の論文
- 2001-05-01
著者
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田中 東
日清食品ホールディングス株式会社食品安全研究所
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東 幸雅
日清食品(株)食品安全研究所
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Tanaka Azuma
Food Safety Research Institute Nissin Food Products Co. Ltd.
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Azuma Yukimasa
Food Safety Research Institute Nissin Food Products Co. Ltd.
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Azuma Yukimasa
Central Research Institute Nissin Food Products Co. Ltd.
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OHNO Katsutoshi
Central Research Institute, Nissin Food Products Co., Ltd.,
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YAMADA Toshihiro
Central Research Institute, Nissin Food Products Co., Ltd.,
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NOBUHARA Yoichi
Central Research Institute, Nissin Food Products Co., Ltd.,
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Nobuhara Yoichi
Central Research Institute Nissin Food Products Co. Ltd.
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Nobuhara Yoichi
Central Research Institute Nissin Food Products Co. Ltd
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Yamada Toshihiro
The Food Safety Research Institute Nissin Foods Holdings Co. Ltd.
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DATE Katsuhiro
Central Research Institute, Nissin Food Products Co., Ltd.
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MATSUSHIRO Shoichiro
Central Research Institute, Nissin Food Products Co., Ltd.
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Date Katsuhiro
Central Research Institute Nissin Food Products Co. Ltd.
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Nobuhara Youichi
Central Research Institute Nissin Food Products Co. Ltd.
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Matsushiro Shoichiro
Central Research Institute Nissin Food Products Co. Ltd.
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Yamada Toshihiro
Food Safety Research Institute Nissin Foods Holdings Co. Ltd.
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