Synthesis of Octahydrobenzo[b]furans Using Tandem Conjugate Addition Reactions Initiated by Oxygen Nucleophile
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概要
- 論文の詳細を見る
When 1-nitrocyclohexene (1) was treated with methyl 4-hydroxy-2-butynoate (2) in the presence of potassium tert-butoxide in tetrahydrofuran-tert-butanol at 0℃ for 10 min, a tandem conjugate addition product, methyl cis-3a-nitrooctahydrobenzo[b]furan-Δ^<3,α>-acetate (3a), was obtained in quantitative yield as a 55 : 45 mixture of the (Z)- and (E)-isomers. The scope and limitations of this reaction were examined. Some transformation reactions of 3a are also described.
- 公益社団法人日本薬学会の論文
- 1998-05-15
著者
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YAKURA Takayuki
Kyoto Pharmaceutical University
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IKEDA Masazumi
Kyoto Pharmaceutical University
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Ikeda M
Kyoto Pharmaceutical University
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YAMADA Seiji
Kyoto Pharmaceutical University
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SHIMA Mari
Kyoto Pharmaceutical University
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IWAMOTO Masae
Kyoto Pharmaceutical University
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Iwamoto M
Kyoto Pharmaceutical University
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