Protective Effect of a Pancreatic Elastase Inhibitor Against a Variety of Acute Pancreatitis in Rats
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概要
- 論文の詳細を見る
Protective effect of trifluoroacetyl-L-lysyl-L-alaninanilide hydrochloride (compound 1), a pancreatic elastase inhibitor, on three types of acute pancreatitis models was examined in rats. Mild, moderate and severe acute pancreatitis were induced by cerulein, the closed duodenal loop method and retrograde injection of a taurocholate plus trypsin solution into the pancreatic duct, respectively. Intravenous infusion of compound 1 at a dose of 30 mg/kg/hr resulted in lower increases in serum amylase, lipase, blood urea nitrogen (BUN) and creatinine levels in rats with mild cerulein-induced edematous pancreatitis. Compound 1 had no beneficial effect on pancreatitis in rats with moderate pancreatitis. In rats with severe pancreatitis, prophylactic treatment of compound 1 (30 mg/kg/hr) reduced both elevated serum BUN level and ascitic volume, and it histologically inhibited the extent of pancreatic edema and hemorrhage. These results suggest that pancreatic elastase is partially responsible for pancreatic edema and hemorrhage exhibited by rats with severe acute pancreatitis.
- 社団法人 日本薬理学会の論文
- 1998-07-01
著者
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Miyata K
Yamanouchi Pharmaceutical Co. Ltd. Ibaraki Jpn
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Miyata K
Yamanouchi Pharmaceutical Co. Ltd. Tsukuba City Jpn
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Miyata Keiji
Pharmacology Laboratories Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.
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Miyata Keiji
Inflammation Research Pharmacology Laboratories Institute For Drug Discovery Research Yamanouchi Pha
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YAMADA Tatsuhiko
Pharmaceutical Laboratories, Kissei Pharmaceutical Co., Ltd.,
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Yamada T
Department Of Radiopharmacy Tohoku Pharmaceutical University
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Miyata K
Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co.
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Yamano Mayumi
Pharmacology Laboratories Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.
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Miyata K
Inflammation Research Pharmacology Laboratories Institute For Drug Discovery Research Yamanouchi Pha
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YAMADA Toshimitsu
Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co. Ltd.
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Yamada Takehisa
Research And Development Division Hokuriku Seiyaku Co. Ltd.
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Miyata K
Hitachi Research Laboratory Hitachi Ltd.
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Yamada Toshimitsu
Pharmacology Laboratories Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.
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Yamano Mayumi
Neuroscience And Gastrointestinal Research Laboratories Institute For Drug Discovery Research Yamano
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