Endothelin Receptor Antagonist Triterpenoid, Myriceric Acid A, Isolated from Myrica cerifera, and Structure Activity Relationships of Its Derivatives
スポンサーリンク
概要
- 論文の詳細を見る
As the first non-peptide endothelin receptor antagonist form a higher plant, a new triter penoid, myiceric acid A (50-235) (1) was isolated from the bayberry, Myrica cerifera. myriceric acid A (1) inhibited not only an endothelin-1-induced increase in cytosolic free Ca^&glt;2+> concentration (IC_<50>=11±2nM) but [^<125&t;I]endothelin-1 binding in rat aortic smooth muscle cells (K_i=66±15nM). Two new related triterpenoids, myriceric acid C (6), and myriceric acid D (8), were also isolated. Furthermore, the chemical modification of these natural products led to the synthesis of sulfated derivative (13,14,15) which showed 1.5 to 20 times higher affinity for endothelin receptors. The structure activity relationships of myriceric acids and their derivatives are discussed.
- 公益社団法人日本薬学会の論文
- 1996-02-15
著者
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IKENISHI Yuji
Shionogi Research Laboratories, Shionogi & Co., Ltd.
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TERUI Yoshihiro
Shionogi Research Laboratories, Shionogi & Co., Ltd.
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SATO Tomohiro
Shionogi Research Laboratories, Shionogi & Co ., Ltd .
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KIKUCHI Junko
Shionogi Research Laboratories, Shionogi & Co ., Ltd .
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KIKUCHI Junko
Department of Bioresources Science, Faculty of Agriculture, Hirosaki University
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Sato T
Tanabe Seiyaku Co. Ltd. Osaka Jpn
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SAKURAWI Kensuke
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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YASUDA Fumio
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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TOZYO Takehiko
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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NAKAMURA Miharu
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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IWATA Tsuyoshi
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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TAKAHASHI Kazuhiro
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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KONOIKE Toshiro
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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MIHARA Shin-ichi
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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FUJIMOTO Masafumi
Shionogi Research Laboratories, Shionogi & Co., Ltd.,
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Yasuda F
Shionogi Research Laboratories Shionogi & Co. Ltd.
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Ikenishi Y
Shionogi Research Laboratories Shionogi & Co. Ltd.
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Kikuchi Junko
Shionogi Research Laboratories Shionogi & Co. Ltd.
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Kikuchi Junko
Department Of Bioresources Science Faculty Of Agriculture Hirosaki University
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Tozyo T
Shionogi Research Laboratories Shionogi & Co. Ltd.
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Tozyo Takehiko
Shionogi Research Laboratories Shionogi & Co. Ltd.
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Iwata Tsuyoshi
Shionogi Research Laboratories Shionogi & Co. Ltd.
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Nakamura Miharu
Shionogi Research Laboratories Shionogi & Co. Ltd.
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Konoike Toshiro
Shionogi Research Laboratories Shionogi & Co. Ltd.
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Terui Yoshihiro
Shionogi Research Laboratories Shionogi & Co. Ltd.
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Sato Tomohiro
Shionogi Research Laboratories Shionogi And Co. Itd.
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Ikenishi Yuji
Shionogi Research Laboratories Shionogi & Co. Ltd.
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Sakurawi K
Shionogi Research Laboratories Shionogi & Co. Ltd.
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Mihara Shin-ichi
Shionogi & Co. Ltd.
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Mihara Shin-ichi
Shionogi Research Laboratories Shionogi & Co. Ltd.
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Yasuda Fumio
Shionogi Research Laboratories Shionogi & Co. Ltd.
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Terui Y
Shionogi Research Laboratories Shionogi & Co. Ltd.
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Fujimoto Masafumi
Shionogi Research Laboratories Shionogi & Co. Ltd.
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Takahashi Kazuhiro
Shionogi Research Laboratories Shionogi & Co. Ltd.
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