Bradykinin-induced cycilc AMP accumulation in mouse fibrosarcoma independent of prostaglandin E2 formation.
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概要
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The relationship between bradykinin (BK)-induced prostaglandin E<SUB>2</SUB> (PGE<SUB>2</SUB>) and cyclic AMP syntheses in mouse fibrosarcoma cells (HSDM<SUB>1</SUB>C<SUB>1</SUB>) was investigated. Maximal BK-induced increases in cyclic AMP preceded increases in PGE<SUB>2</SUB> production. PGE<SUB>2</SUB> synthesis reached maximum at a much lower concentration of BK than cyclic AMP synthesis. Indomethacin completely inhibited BK-induced PGE<SUB>2</SUB> production, but did not influence the cyclic AMP levels. Arachidonic acid in the medium induced PGE<SUB>2</SUB> production in large quantities, but increased cyclic AMP accumulation only slightly. A high PGE<SUB>2</SUB> concentration increased cyclic AMP levels only slightly. Theophylline increased basal and BK-mediated cyclic AMP levels, but did not affect PGE<SUB>2</SUB> production at all. These results indicate that BK-evoked PGE<SUB>2</SUB> and cyclic AMP syntheses in HSDM<SUB>1</SUB>C<SUB>1</SUB> are not dependent upon each other.
- 公益社団法人 日本薬理学会の論文
著者
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Fujimoto Masafumi
Shionogi Research Laboratories Shionogi & Co. Ltd.
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OKABAYASHI TADASHI
Shionogi Research Laboratory, Shionogi & Co., Ltd.
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OKABAYASHI Tadashi
Shionogi Research Laboratories, Shionogi & Co., Ltd.
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