Solubility Method Using Static Head-Space Gas Chromatography for Determination of the Stability Constants of Fragrance Materials with 2-Hydroxypropyl-β-cyclodextrin
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概要
- 論文の詳細を見る
The stability constants for the inclusion of fragrance materials with 2-hydroxypropyl-β-cyclodextrin (2HP-β-CyD) in aqueous solution have been determined at 25℃ by a solubility method. The solubility of fragrance in 2HP-β-CyD solution was determined from the concentration of fragrance in vapor which was in equilibrium with that in the solution using static head-space gas chromatography (SHSGC). The stability constants of (+)-limonene and linalool obtained by this method were in rough accord with the reported values. Because of its advantages of simplicity, less amount of guest used and the ease of temperature control, it was concluded that the SHSGC method is another useful technique for determining the solubility and stability constant of a volatile guest/CyD system in aqueous medium.
- 公益社団法人日本薬学会の論文
- 1998-03-15
著者
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SAITO Yoshihiro
College of Pharmacy, Nihon University
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Saito Yoshihiro
College Of Pharmacy Nihon University
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Ueda H
Faculty Of Pharmaceutical Sciences Josai University
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Ueda H
Kyoto Pharmaceutical University
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UEDA Haruhisa
Faculty of Pharmaceutical Science, Hoshi University
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Ueda H
Hoshi Univ. Tokyo Jpn
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Ueda H
Department Of Physical Chemistry Hoshi University
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Ueda H
Faculty Of Pharmaceutical Sciences Hoshi University
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Ueda Haruhisa
Research Institute For Scientific Measurements Tohoku University
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Ueda Haruhisa
Faculty Of Pharmaceutical Science Hoshi University
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Ueda Hideo
Fac. Of Pharmaceutical Sciences Josai Univ.
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SATO Takatoshi
College of Pharmacy, Nihon University
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Sato T
Tanabe Seiyaku Co. Ltd. Osaka Jpn
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Ueda H
Fac. Of Pharmaceutical Sciences Josai Univ.
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上田 仁司
Kawanishi Pharma Research Institute Nippon Boehringer Ingelheim Co. Ltd.
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TANEMURA Izumi
College of Pharmacy, Nihon University
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Tanemura Izumi
College Of Pharmacy Nihon University
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Saito Y
Analysis & Quality Control Department Takeda Chemical Industries Ltd.
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