Calorimetry and Cryo-Transmission Electron Microscopic Studies of PEG2000-Grafted Liposomes
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概要
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The phase behavior of poly (ethylene glycol) grafted liposomes (PEG-liposomes) was investigated by differential scanning calorimetry (DSC), dynamic light scattering (DLS) and cryo-transmission electron microscopy (cryo-TEM). PEG-liposomes were prepared from mixtures of dipalmitoyl phosphatidylcholine (DPPC) and distearoyl phosphatidylethanolamine with a covalently attached PEG molecular weight of 2000 (DSPE-PEG2000). From the results of DLS measurements, the coexistence of PEG-liposomes and small molecular assemblies were confirmed at mole fractions of DSPE-PEG2000 above about 0.1. Moreover, it was confirmed that small molecular assemblies were disk micelles by cryo-TEM. However, the phase transition enthalpies of PEG-liposomes were hardly changed according to the DSC measurement, though the mole fraction of the PEG lipid increased. From these results, it was suggested that the phase transition enthalpies hardly changed despite mixed micelles being formed because the bilayer structure of the disk micelle maintains high cooperativity between the DPPC molecules.
- 社団法人日本薬学会の論文
- 2006-04-01
著者
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Sakai Hideki
Faculty of Science and Technology, Tokyo University of Science
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Abe Masahiko
Faculty of Science and Technology, Tokyo University of Science
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酒井 秀樹
東京理科大学理工学部工業化学科
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HASHIZAKI Kaname
College of Pharmacy, Nihon University
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TAGUCHI Hiroyuki
College of Pharmacy, Nihon University
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SAITO Yoshihiro
College of Pharmacy, Nihon University
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TSUCHIYA Koji
Faculty of Science and Technology, Tokyo University of Science
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Sakai Hideki
Dep. Of Pure And Applied Chemistry Fac. Of Sci. And Technol. Tokyo Univ. Of Sci.
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Saito Yoshihiro
College Of Pharmacy Nihon University
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Tsuchiya Koji
Dep. Of Pure And Applied Chemistry In Fac. Of Sci. And Technol. And Res. Inst. For Sci. And Technol.
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Taguchi Hiroyuki
College Of Pharmacy Nihon University
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Abe Masahiko
Fac. Of Sci. And Technol. Tokyo Univ. Of Sci.
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Abe Masahiko
東京理科大学 理工学部
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Hashizaki K
College Of Pharmacy Nihon University
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Hashizaki Kaname
日本大学 薬学部
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Hashizaki Kaname
Faculty Of Science And Technology Science University Of Tokyo
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Abe Masahiko
Faculty Of Science And Technology Science University Of Tokyo
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OGAWA Naotake
College of Pharmacy, Nihon University
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Abe Masahiko
Faculty Of Science And Technology Tokyo University Of Science
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Saito Yoshihiro
国立病院機構大阪医療センター 眼科
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酒井 秀樹
東京理科大学
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Ogawa N
College Of Pharmacy Nihon University
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Ogawa Naotake
College Of Pharmacy Nihon University
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Taguchi H
Kobe Pharmaceutical Univ. Kobe Jpn
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Hashizaki Kaname
College Of Pharmacy Nihon University
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齊戸 美弘
Department Of Ophthalmology Osaka National Hospital
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Abe M
Faculty Of Science And Technology Science University Of Tokyo
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Abe Masahiko
Department Of Pure And Applied Chemistry Tokyo University Of Science
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Saito Yutaka
Osaka University Of Pharmaceutical Sciences:faculty Of Pharmaceutical Sciences Okayama University:ch
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TSUCHIYA Koji
Faculty of Science and Technology, Science University of Tokyo
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SAKAI Hideki
Faculty of Science and Technology, Science University of Tokyo
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