Effects of Dialkyldimethylammonium Bromides on the Membrane Properties of Cationic Liposomes
スポンサーリンク
概要
- 論文の詳細を見る
Cationic liposomes composed of dipalmitoylphosphatidylcholine (DPPC) and dialkyldimethylammonium bromides (DLAB, DMAB, DPAB or DSAB) were prepared by the Bangham method, and the effect of the alkyl chain length of dialkyldimethylammonium bromide on the membrane properties of the liposomes was examined in terms of the trapping efficiency, liposomal shape and phase transition temperature. Furthermore, the effect of stearylamine (SA) on the liposomal membrane properties was also investigated. Large unilamellar vesicles (LUVs) with a diameter of approximately 1.0∼1.5 μm were formed by mixing small amounts of cationic substances, not only dialkyldimethylammonium bromides, but also SA. The trapping efficiency of the mixed liposomes was greater than that of the DPPC liposomes since the DPPC liposomes were multilamellar vesicles. The maximum trapping efficiency of the mixed liposomes was obtained at 0.05 mole fractions of the cationic substances. Furthermore, dialkyldimethylammmonium bromides with longer alkyl chains, DSAB, DPAB and DMAB, formed cationic substance-rich liposomes with DPPC, and they had the second maximum trapping efficiency at 0.75∼0.9 mole fractions of cationic substance.
- 日本油化学会の論文
著者
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Sakai Hideki
Faculty of Science and Technology, Tokyo University of Science
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Abe Masahiko
Faculty of Science and Technology, Tokyo University of Science
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酒井 秀樹
東京理科大学理工学部工業化学科
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TSUCHIYA Koji
Faculty of Science and Technology, Tokyo University of Science
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Sakai Hideki
Dep. Of Pure And Applied Chemistry Fac. Of Sci. And Technol. Tokyo Univ. Of Sci.
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Tsuchiya Koji
Dep. Of Pure And Applied Chemistry In Fac. Of Sci. And Technol. And Res. Inst. For Sci. And Technol.
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Abe Masahiko
Faculty Of Science And Technology Science University Of Tokyo
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YOKOYAMA Shoko
School of Pharmaceutical Sciences, Kyushu University of Health and Welfare
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OHKUBO Takahiro
Faculty of Science and Technology, Tokyo University of Science
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IMURA Tomohiro
Faculty of Science and Technology, Tokyo University of Science
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Inagaki Akiko
Faculty of Science and Technology, Tokyo Universtity of Science
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TSUBAKI Nobuyuki
Oleochemicals Research Lab., NOF Co.
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Inagaki A
Japan Sci. And Technol. Corp.(jst) Tokyo Jpn
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Yokoyama Shoko
School Of Pharmaceutical Sciences Kyushu University Of Health And Welfare
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Imura Tomohiro
Faculty Of Science And Technology Science University Of Tokyo
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TSUCHIYA Koji
Faculty of Science and Technology, Science University of Tokyo
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SAKAI Hideki
Faculty of Science and Technology, Science University of Tokyo
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