Emulsifying Potency of New Amino Acid-Type Surfactant(II) : Stable Water-in-Oil(W/O)Emulsions Containing 85wt% Inner Water Phase

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The ternary phase diagram for N-[3-lauryloxy-2-hydroxypropyl]-L-arginine L-glutamate(C12HEA-Glu), a new amino acid-type surfactant, /oleic acid(OA)/water system was established. The liquid crystal and gel complex formations between C12HEA-Glu and OA were applied to a preparation of water-in-oil(W/O)emulsions. Stable W/O emulsions containing liquid paraffin(LP)as the oil and a mixture of C12HEA-Glu and OA as the emulsifier were formed. The preparation of stable W/O emulsions containing 85wt% water phase was also possible, in which water droplets would be polygonally transformed and closely packed, since the maximum percentage of inner phase is 74% assuming uniformly spherical droplets. Water droplets would be taken into the liquid crystalline phase(or the gel complex)and the immovable water droplets would stabilize the W/O emulsion system. The viscosity of emulsions abruptly increased above the 75wt% water phase(dispersed phase). The stability of W/O emulsions with a lower weight ratio of OA to C12HEA-Glu and a higher ratio of water phase was greater. This unusual phenomenon may be related to the formation of a liquid crystalline phase between C12HEA-Glu and OA, and the stability of the liquid crystal at a lower ratio of oil(continuous phase). W/O and oil-in-water(O/W)emulsions containing LP were selectively prepared using a mixture of C12HEA-Glu and OA since the desirable hydrophile-lipophile balance(HLB)number for the emulsification was obtainable by mixing the two emulsifiers.
公益社団法人日本薬学会の論文
2001-10-01

Emulsifying Potency of New Amino Acid-Type Surfactant(II) : Stable Water-in-Oil(W/O)Emulsions Containing 85wt% Inner Water Phase

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