Stearylamine Changes the Liposomal Shape from MLVs to LUVs
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概要
- 論文の詳細を見る
The shape of mixed dipalmitoylphosphatidylcholine (DPPC)/stearylamine (SA) liposomes prepared by the Bangham method was examined using freeze-fracture electron microscopy. The shape of the mixed DPPC/SA liposomes (XSA = 0.05) was not that of multilamellar vesicles (MLVs) but large unilamellar vesicles (LUVs) with a diameter of approximately 1.0 μm. These facts overthrow the preconceived idea that the shape of the DPPC/SA liposomes prepared by the Bangham method is that of MLVs. The trapping efficiency of the mixed DPPC/SA liposomes (XSA = 0.05) was ten times greater than that of the DPPC liposomes, since the DPPC liposomes were MLVs. The data of the DSC peak for the DPPC/SA liposomes also indicated that the shape of the DPPC/SA liposomes is that of LUVs. We emphasize that the shape of the DPPC liposomes changes from that of MLVs to LUVs by the mixing of a small amount of SA into the DPPC liposomes.
- 日本油化学会の論文
著者
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Sakai Hideki
Faculty of Science and Technology, Tokyo University of Science
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Abe Masahiko
Faculty of Science and Technology, Tokyo University of Science
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TSUCHIYA Koji
Faculty of Science and Technology, Tokyo University of Science
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Tsuchiya Koji
Dep. Of Pure And Applied Chemistry In Fac. Of Sci. And Technol. And Res. Inst. For Sci. And Technol.
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Abe Masahiko
Faculty Of Science And Technology Science University Of Tokyo
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YOKOYAMA Shoko
School of Pharmaceutical Sciences, Kyushu University of Health and Welfare
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OHKUBO Takahiro
Faculty of Science and Technology, Tokyo University of Science
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IMURA Tomohiro
Faculty of Science and Technology, Tokyo University of Science
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Inagaki Akiko
Faculty of Science and Technology, Tokyo Universtity of Science
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TSUBAKI Nobuyuki
Oleochemicals Research Lab., NOF Co.
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Inagaki A
Japan Sci. And Technol. Corp.(jst) Tokyo Jpn
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Yokoyama Shoko
School Of Pharmaceutical Sciences Kyushu University Of Health And Welfare
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Imura Tomohiro
Faculty Of Science And Technology Science University Of Tokyo
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Yokoyama S
Kyushu Univ. Health And Welfare Miyazaki Jpn
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TSUCHIYA Koji
Faculty of Science and Technology, Science University of Tokyo
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SAKAI Hideki
Faculty of Science and Technology, Tokyo Universtity of Science
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SAKAI Hideki
Faculty of Science and Technology, Science University of Tokyo
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IMURA Tomohiro
Faculty of Science and Technology, Tokyo Universtity of Science
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