Effect of Matrix on Surface Pressure-Responsive Morphological Change of Ganglioside G_<M1> (GM1), Related to the Individual Role of GM1 in Each Organ?

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概要

• 論文の詳細を見る

• The surface states of ganglioside GM1 (GM1) / dipalmitoylphosphatidylcholine (DPPC), GM1/dioleoylphosphatidylcholine (DOPC) and GM1/DPPC/DOPC monolayers were investigated using atomic force microscopy (AFM), and the effect of surface pressure on the surface states of the membranes was examined. Specific changes in morphology were observed in the GM1/DPPC and GM1/DPPC/DOPC monolayers when the surface pressure was varied from 30 to 40 mN m-1, while no significant morphological change was detected in the GM1/DOPC monolayer. GM1 was likely to bring about a change in morphology in the liquid-condensed film but not the liquid-expanded film. Nevertheless, the changes to monolayers with surface pressure support the participation of GM1 in signal transduction or specific cell recognition. Furthermore, the surface pressure-responsive change in morphology of GM1 was affected by the matrix, suggesting that the GM1 localized to each organ has a specific role.

• 日本油化学会の論文
• 2004-02-01

著者

• Sakai Hideki

  Faculty of Science and Technology, Tokyo University of Science

• Abe Masahiko

  Faculty of Science and Technology, Tokyo University of Science

• Abe Masahiko

  Fac. Of Sci. And Technol. Tokyo Univ. Of Sci.

• Abe Masahiko

  東京理科大学 理工学部

• TAKEDA Tadahiro

  Kyoritsu University of Pharmacy

• Imura Tomohiro

  Research Institute For Innovation In Sustainable Chemistry National Institute Of Advanced Science An

• Imura T

  National Institute Of Advanced Industrial Science And Technology (aist)

• Imura Tomohiro

  National Institute Of Advanced Industrial Science And Technology (aist)

• Abe Masahiko

  Faculty Of Science And Technology Science University Of Tokyo

• YOKOYAMA Shoko

  School of Pharmaceutical Sciences, Kyushu University of Health and Welfare

• Abe Masahiko

  Faculty Of Science And Technology Tokyo University Of Science

• OHTA Yumiko

  Faculty of Science and Technology, Tokyo University of Science

• IMURA Tomohiro

  Faculty of Science and Technology, Tokyo University of Science

• 酒井 秀樹

  東京理科大学

• TABOHASHI Tatsuru

  Ajinomoto Co., Inc., Amino Science Laboratories

• Ohta Yumiko

  Faculty Of Science And Technology Tokyo University Of Science

• Tabohashi Tatsuru

  Ajinomoto Co. Inc. Amino Science Laboratories

• Yokoyama Shoko

  School Of Pharmaceutical Sciences Kyushu University Of Health And Welfare

• Imura Tomohiro

  Faculty Of Science And Technology Science University Of Tokyo

• Takeda Tadahiro

  Kyoritsu College Of Pharmacy

• Imura Tomohiro

  National Institute Of Advanced Industrial Science And Technology

• Yokoyama S

  Kyoritsu College Of Pharmacy

• Yokoyama S

  Kyushu Univ. Health And Welfare Miyazaki Jpn

• Takeda Tadahiro

  Kyoritsu College Of Pharmac

• Abe M

  Faculty Of Science And Technology Science University Of Tokyo

• SAKAI Hideki

  Faculty of Science and Technology, Science University of Tokyo

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