Relationship between Hydrophobic Index of Saccharide and Gel-Liquid Crystal Transition Temperature of the L-α-Dipalmitoyl Phosphatidylcholine (DPPC)/Saccharide/Water System

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An examination of the relationship between the hydrophobic index of saccharide and gel-liquid crystal transition temperatures in L-α-dipalmitoly phosphatidylcholine (DPPC)/saccharide systems at a water content of 10 wt% and 70 wt% was performed using differential scanning calorimetry. Saccharide at 10 wt% water was found to interact with phospholipids hydrophobically via the hydrophobicity-rich side of the pyranose ring. Molar ratios (pyranose ring/DPPC) were determined as 2 for the DPPC/rhamnose system with 8.2 wt% water and for the DPPC/trehalose system at 15.8 wt%. Pyranose would thus appear to form a 2 : 1 complex with lipid that faces the hydrophobicity-rich side of the pyranose ring. Saccharide with 70 wt% water interacted with the phospholipid hydrophilically through hydration of the saccharide.
公益社団法人日本薬学会の論文
1999-05-15