Efficient Preparation of Optically Active (S)-(-)-3-Methyl-γ-butyrolactone by Catalytic Asymmetric Hydrogenation Using Chiral N-Substituted Pyrrolidinebisphosphine Rhodium Complexes

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概要

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• (S)-(-)-2-Methyl succinamic acid, which is a good precursor of (S)-(-)-3-methyl-γ-butyrolactone, can be prepared by homogeneous asymmetric hydrogenation of 2-methylene succinamic acid catalyzed by (2S, 4S)-N-substituted-4-(diphenylphosphino)-2-[(diphenylphosphino)-methyl]pyrrolidine-rhodium complexes. Various N-substituted pyrrolidine-bisphosphines were synthesized to find the optimum ligand for this purpose and to compare the effects of the N-substituents.

• 社団法人日本薬学会の論文
• 1991-10-25

著者

• 阿知波 一雄

  School of Pharmaceutical Sciences, University of Shizuoka

• 井口 潔

  School Of Pharmaceutical Sciences University Of Shizuoka

• 竹田 栄夫

  Research Division, Fuji Chemical Industries, Ltd.,

• 立浪 毅

  Research Division, Fuji Chemical Industries, Ltd.,

• 細川 滋樹

  Research Division, Fuji Chemical Industries, Ltd.,

• 油谷 政和

  Research Division, Fuji Chemical Industries, Ltd.,

• 竹田 栄夫

  Research Division Fuji Chemical Industries Ltd.

• 立浪 毅

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 油谷 政和

  Research Division Fuji Chemical Industries Ltd.

• 立浪 毅

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 細川 滋樹

  Research Division Fuji Chemical Industries Ltd.

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