Studies on Quinolizinium Salts. IX. Ring-Opening Reactions of Benzo [α]-and Benzo [c] quinolizinium Bromides with a Grignard Reagent and Geometrical Determinations of the Resultant Butadienes

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概要

• 論文の詳細を見る

• Benzo [c]-and benzo [α] quinolizinium bromides (X and XIII) were reacted with phenylmagnesium bromide in order to examine their chemical reactivities. Ring opening reactions occurred with preferential attack of the nucleophile at C-1 for X and C-4 for XIII to give phenylbutadienylquinoline (XII) and isoquinoline (XV), respectively. In connection with the structural determination of XII and XV, the nuclear magnetic resonance spectra of phenylbutadienylpyridine derivatives (VII and its derivatives) were compared with calculated spectra. The calculated band positions and intensities of the olefinic protons are in accord with the observed values.

• 社団法人日本薬学会の論文
• 1978-08-25

著者

• 宮寺 哲男

  Central Research Laboratories, Sankyo Co., Ltd.

• 桑野 晴光

  Central Research Laboratories, Sankyo Co., Ltd.

• 桑野 晴光

  Analytical and Metabolic Research Laboratories

• 高岸 靖

  Developmental Research Laboratories Shionogi & Co. Ltd.

• 宮寺 哲男

  Chemical Research Laboratories, Sankyo Co., Ltd.

• 川野 洋一

  Central Research Laboratories, Sankyo Co., Ltd.

• 川野 洋一

  Central Research Laboratories Sankyo Co. Ltd.

• 高岸 靖

  Central Research Laboratories, Sankyo Co., Ltd.

• 宮寺 哲男

  Chemical Research Laboratories Sankyo Co. Ltd.

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