Synthesis of a Tricyclic Benzodiazepine Derivative from Chlordiazepoxide and X-Ray Crystallographic Analysis of a Rearrangement Product, the Indolenine Derivative
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概要
- 論文の詳細を見る
The oxazolidone-fused benzodiazepine derivative (1) was prepared by treatment of chlordiazepoxide (2) with sodium hydride and ethyl chloroformate followed by the N-oxide rearrangement of the resultant carbamate (3) with acetic anhydride. The first reaction was found to be accompanied by a multi-step rearrangement of the initially formed 3 as a side reaction giving rise to the indolenine derivative (4). The structure of 4 was determined by X-ray crystallographic analysis.
- 公益社団法人日本薬学会の論文
- 1981-08-25
著者
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宮寺 哲男
Central Research Laboratories, Sankyo Co., Ltd.
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太刀川 隆治
Central Research Laboratories, Sankyo Co., Ltd.
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田村 千尋
Central Research Laboratories Sankyo Co., Ltd.
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畠 忠
Central Research Laboratories, Sankyo Co., Ltd.
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太刀川 隆治
Central Research Laboratories Sankyo Co. Ltd.
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宮寺 哲男
Chemical Research Laboratories, Sankyo Co., Ltd.
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畠 忠
Central Research Laboratories Sankyo Co. Ltd.
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畑 忠
Central Research Laboratories, Sankyo Co., Ltd.
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宮寺 哲男
Chemical Research Laboratories Sankyo Co. Ltd.
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田村 千尋
Central Research Laboratories Sankyo Co. Ltd.
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