3-Trifluoromethylcephalosporins. II. Synthesis and in Vitro Antibacterial Activities of 3-Trifluoromethylcephalosporin Derivatives

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概要

• 論文の詳細を見る

• Various acylamido derivatives of 3-trifluoromethyl-3-cephem-4-carboxylic acid were synthesized and tested for in vitro antibacterial activities. The 3-trifluoromethylcephalosporin derivatives synthesized herein are 7α- and 7β-acylamido-3-cephem-, 7α- methoxy-7β-acylamido-3-cephem- and 7β-acylamido-2-cephem-4-carboxylic acids. Among these compounds, the R-mandelamido derivative (IIIb) showed the highest antibacterial activity against gram-negative bacteria at pH 7.0. The minimum inhibitory concentration values of the 2-thienylacetamido- and phenylglycylamido derivatives are compared with those of the 3-methyl- and 3-chloro analogs, and structure-activity relationships are discussed.

• 社団法人日本薬学会の論文
• 1980-01-25

著者

• 宮寺 哲男

  Central Research Laboratories, Sankyo Co., Ltd.

• 渡辺 泰一郎

  Chemical Research Laboratories Sankyo Co. Ltd.

• 西村 卓三

  Central Research Laboratories Sankyo Co., Ltd.

• 渡辺 泰一郎

  Central Research Laboratories, Sankyo Co., Ltd.

• 宮寺 哲男

  Chemical Research Laboratories, Sankyo Co., Ltd.

• 川野 洋一

  Central Research Laboratories, Sankyo Co., Ltd.

• 酒井 純一

  Central Research Laboratories, Sankyo Co., Ltd.

• 渡辺 英俊

  Central Research Laboratories, Sankyo Co., Ltd.

• 長野 光男

  Central Research Laboratories, Sankyo Co., Ltd.

• 渡辺 英俊

  Chemical Research Laboratories Sankyo Co. Ltd.

• 川野 洋一

  Central Research Laboratories Sankyo Co. Ltd.

• 宮寺 哲男

  Chemical Research Laboratories Sankyo Co. Ltd.

• 酒井 純一

  Central Research Laboratories Sankyo Co. Ltd.

• 長野 光男

  Central Research Laboratories Sankyo Co. Ltd.

• 西村 卓三

  Central Research Laboratories Sankyo Co. Ltd.

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