Quantitative Structure-activity Relationships in Minor Tranquilizers Benzodiazepinooxazole Derivatives

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概要

• 論文の詳細を見る

• Quantitative structure-activity relationships (QSAR) for benzodiazepinooxazoles were formulated in 9 equations correlating chemical structure with 9 types of biological activities. The equations describing the relationships are log 1/C=aπ-7+bF-3+cF-4+dI-1+eI-2+fI-3+g where C is the molar concentration causing 50% biological activity, π-7 is the hydrophobic constant for substituents on the N^7 position of 1,4-diazepine (II), F-3 and F-4 refer to the electronic effects of R^3 and R^4,respectively, and the indicator variable I-1,I-2 and I-3 refer to the methyl function of the R^3,R^9 and R^<10>, respectively.

• 社団法人日本薬学会の論文
• 1977-06-25

著者

• 高木 弘

  Central Research Laboratories Sankyo Co. Ltd.

• 吉本 昌文

  Central Research Laboratories, Sankyo Co., Ltd.

• 上岡 利春

  Central Research Laboratories, Sankyo Co., Ltd.

• 宮寺 哲男

  Central Research Laboratories, Sankyo Co., Ltd.

• 小林 晋作

  Central Research Laboratories, Sankyo Co., Ltd.

• 太刀川 隆治

  Central Research Laboratories, Sankyo Co., Ltd.

• 吉本 昌文

  Chemical Research Laboratories Sankyo Co. Ltd.

• 太刀川 隆治

  Central Research Laboratories Sankyo Co. Ltd.

• 宮寺 哲男

  Chemical Research Laboratories, Sankyo Co., Ltd.

• 上岡 利春

  Biological Research Laboratories, Sankyo Co., Ltd.

• 小林 晋作

  Central Research Laboratories Sankyo Co. Ltd.

• 上岡 利春

  Biological Research Laboratories Sankyo Co. Ltd.

• 宮寺 哲男

  Chemical Research Laboratories Sankyo Co. Ltd.

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