Synthesis and Biological Activity of Tetragastrin Analogues modifying the Tryptophan Residue
スポンサーリンク
概要
- 論文の詳細を見る
Three analogues of tetragastrin, in which the tryptophan residue was substituted by 3-(1-naphthyl)-L-alanine, 3-(2-naphthyl)-L-alanine or 1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid, were synthesized and evaluated for their gastric juice stimulating activity. The results suggest that the indolyl NH function in the tryptophan residue plays an important role and that the role of the tryptophan residue in an interaction between tetragastrin and its receptor is different from that in the case of luteinizing hormonereleasing hormone.
- 公益社団法人日本薬学会の論文
- 1977-10-25
著者
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小林 晋作
Central Research Laboratories, Sankyo Co., Ltd.
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森田 明
Central Research Laboratories, Sankyo Co., Ltd.
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馬場 義彦
Central Research Laboratories, Sankyo Co., Ltd.
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矢部 裕一郎
Central Research Laboratories, Sankyo Co., Ltd.
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三浦 千枝子
Central Research Laboratories, Sankyo Co., Ltd.
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小林 晋作
Central Research Laboratories Sankyo Co. Ltd.
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矢部 裕一郎
Exploratory Chemistry Research Sankyo Co. Ltd.
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馬場 義彦
Central Research Laboratories Sankyo Co. Ltd
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三浦 千枝子
Central Research Laboratories Sankyo Co. Ltd
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森田 明
Central Research Laboratories Sankyo Co. Ltd.
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