FEVER RESPONSES TO BACTERIAL PYROGENS IN GUINEA PIGS AND APPLICATION FOR SCREENING OF ANTIPYRETIC AGENTS

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It is well known that the parenteral use of bacterial pyrogen produces fever reaction in men, dogs, cats and rabbits. From the practical reason of easier management, rabbits have been widely used for pyrogen test as well as for screening of the antipyretic activity of different kinds of compounds. But it is a big advantage if the smaller animals can be used for screening of antipyretic agents. Recently, Winter et al. (1) and Yamada et al. (2) reported a marked rise of rectal temperature of rats with one or two hours latency, when bacterial lipopolysaccharide was used as pyrogen. Based on this finding, Winter et al. adapted this response to the screening of antipyretic agents. In the authors laboratory, any detectable fever response by bacterial lipopolysaccharide is not obtained in rats, while the definite pyretic effect of a bacterial lipopolysaccharide and typhoid-paratyphoid vaccine is observed in guinea pigs. Moreover, antipyretic effect of different structure of compound is successfully screened in fevered guinea pigs.
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