Studies on New β-Adrenergic Blocking Agents. I. Syntheses and Pharmacology of Coumarin Derivatives
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概要
- 論文の詳細を見る
Several (2-hydroxy-3-aminopropoxy) coumarin derivatives were synthesized from 5-, 7- and 8-hydroxycoumarin derivatives by established methods and β-adrenergic blocking activity was examined. A systematic study of the positional isomers in the coumarin derivatives showed that 5-methyl-8-(2-hydroxy-3-t-butylaminopropoxy) coumarin (XXIIa_2) was most favorable as a β-adrenergic blocking agent. It was shown that the classical structure requirement prevailed, but 7-positional isomer was much less active. Resolution of XXIIa_2 revealed that the 1-isomer possessed the major activity.
- 社団法人日本薬学会の論文
- 1972-05-25
著者
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高木 弘
Central Research Laboratories Sankyo Co. Ltd.
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佐藤 裕信
Central Research Laboratories Sankyo Co. Ltd.
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佐藤 裕信
三共株式会社中央研究所
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中山 貢一
Department Of Pharmacology University Of Shizuoka School Of Pharmaceutical Sciences
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小池 博之
三共株式会社中央研究所
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熊倉 清次
Central Research Laboratories, Sankyo Co., Ltd.
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小池 博之
Central Research Laboratories, Sankyo Co., Ltd.
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大島 武史
Central Research Laboratories, Sankyo Co., Ltd.
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小林 裕
Central Research Laboratories, Sankyo Co., Ltd.
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長崎 隆
Central Research Laboratories, Sankyo Co., Ltd.
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中山 貢一
Central Research Laboratories, Sankyo Co., Ltd.
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熊倉 清次
三共株式会社中央研究所
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大島 武史
And Biological Research Laboratories:sankyo Co. Ltd.
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長崎 隆
Central Research Laboratories Sankyo Co. Ltd.
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小林 裕
Central Research Laboratories Sankyo Co. Ltd.
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中山 貢一
Central Research Laboratories Sankyo Co. Ltd.
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