Studies on Seven-membered Ring Compounds. XXIV. Syntheses of 8-Methylimino cyclohepta [b] pyrrole and Cyclohepta [b] pyrrole-8(1H)-thione Derivatives and Tropone Analogues of Tryptamine
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概要
- 論文の詳細を見る
8-Methylimino-1,8-dihydrocyclohepta [b] pyrrole derivatives (XIa〜d) were synthesized by cyclization of azines obtained from 2-methylaminotropone hydrazone and various carbonyl compounds. Direct methylation of cyclohepta [b] pyrrol-8(1H)-one derivatives with dimethyl sulfate resulted in O-methylation affording 8-methoxycyclohepta [b] pyrroles (XVa〜c) which on condensation with methylmine also gave XIa〜c. Cyclohepta [b] pyrrole-8(1H)-thione derivatives were synthesized by reaction of XVa〜c and sodium sulfide. In addition, tropone analogues of tryptamine, 3-(2-aminoethyl) cyclohepta [b] pyrrole derivatives were prepared.
- 社団法人日本薬学会の論文
- 1967-05-25
著者
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佐藤 裕信
Central Research Laboratories Sankyo Co. Ltd.
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砂川 玄俊
Central Research Laboratories Sankyo Co. Ltd.
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