Studies on Seven-membered Ring Compounds. VIII. Syntheses of 5-Nitrosotropolone Derivatives.
スポンサーリンク
概要
- 論文の詳細を見る
3-Substituted 5-nitrosotropolone (IIIa〜c), 7H-cyclohepta [b] pyrazin-7-one oxime (VIIIa, b), 8H-cyclohepta [b] quinoxalin-8-one oxime (IXa〜c), 9H-cyclohepta [b] naphtho [2,3-e] pyrazin-9-one oxime (X), 5-nitrosotropolone guanidine adduct (XI), 2-(2-acetylhydrazino)-5-nitrosotropone (XII and its analogues) and 2-(2-troponylhydrazino)-5-nitrosotropone (XIV) were synthesized according to the schemes shown in Chart 1,2,and 3. In addition, some reactions related to IIIa and IIIc were described. Among these derivatives, 2-(2-isonicotinoylhydrazino)-5-nitrosotropone and its N-oxide showed remarkable anti-tumor activities on ascitic and solid forms of Ehrlich tumor and Sarcoma 180.
- 社団法人日本薬学会の論文
- 1963-11-25
著者
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佐藤 裕信
Central Research Laboratories Sankyo Co. Ltd.
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砂川 玄俊
Central Research Laboratories Sankyo Co. Ltd.
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砂川 玄俊
Takamine Research Laboratory Sankyo Co. Ltd.
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綿谷 充雄
Central Research Laboratories, Sankyo Co., Ltd.
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佐藤 裕信
Takamine Research Laboratory, Sankyo Co., Ltd.
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綿谷 充雄
Takamine Research Laboratory, Sankyo Co., Ltd.
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綿谷 充雄
Central Research Laboratories Sankyo Co. Ltd.
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