Synthetic Studies on 2,4-Benzothiazepin-5 (1H)-one and 2,4-Benzodiazepin-1-one Derivatives
スポンサーリンク
概要
- 論文の詳細を見る
2,4-Benzothiazepin-5 (1H)-one were usually the predominant products in reactions of o-chloromethylbenzoyl chloride with 1,3-disubstituted thioureas ; but with methyl, benzyl or allyl substituted thioureas, 2,4-benzodiazepin-1-ones were obtained together with 2,4-benzothiazepin-5 (1H)-ones. These structures were elucidated from infrared, ultraviolet and nuclear magnetic resonance spectra. We also found that nature of the base and solvent as well as thiourea substituents affected the course of the reactions affording 2,4-benzothiazepin-5 (1H)-ones or 2,4-benzodiazepin-1-ones. Several 2,4-benzothiazepin-5 (1H)-ones and 2,4-benzodiazepin-1-ones possessed weak pharmacological activities, such as coronary vasodilating and local anesthetic activity.
- 公益社団法人日本薬学会の論文
- 1975-08-25
著者
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佐藤 裕信
Central Research Laboratories Sankyo Co. Ltd.
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藤田 弘
三共株式会社中央研究所
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藤田 弘
Central Research Laboratories, Sankyo Co., Ltd.
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