Studies on Seven-membered Ring Compounds. XVII. Alkylation of Cycloheptimidazolone and Cyclohepta[b]pyrrolone
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概要
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In an effort to obtain active analgesic and anti-inflammatory agents, alkylation of cycloheptimidazolone and cyclohepta[b]pyrrolone was carried out. Benzylation of 4-and 6-hydroxycycloheptimidazol-2(1H)-one afforded 1-benzyl and 1,3-dibenzyl derivatives. Benzylation of cyclohepta[b]pyrrol-2(1H)-one afforded 1-and 3-benzyl derivatives. Benzylation of cyclohepta[b]pyrrole-2,8(1H, 3H)-dione which is considered to be present in many tautomers afforded 3-benzyl, 3,3-and 1,3-dibenzyl, 1,3,3-tribenzyl and 1,3-dibenzyl-8-benzyloxy derivatives. By the alkylation of cycloheptimidazol-2(1H)-one and 3-substituted cyclohepta[b]pyrrol-8(1H)-one, a number of 1-alkyl derivatives were prepared. Among these products, 1-benzylcycloheptimidazol-2(1H)-one has been found to be the most active analgesic and anti-inflammatory agent.
- 社団法人日本薬学会の論文
- 1965-04-25
著者
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佐藤 裕信
Central Research Laboratories Sankyo Co. Ltd.
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砂川 玄俊
Central Research Laboratories Sankyo Co. Ltd.
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相馬 信夫
Central Research Laboratories, Sankyo Co., Ltd.
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中尾 英雄
Research Laboratories, Sankyo Co., Ltd.
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相馬 信夫
Research Laboratories, Sankyo Co., Ltd.
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砂川 玄俊
Research Laboratories, Sankyo Co., Ltd.
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佐藤 裕信
Research Laboratories, Sankyo Co., Ltd.
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中尾 英雄
Sankyo Research Laboratories, Sankyo Co., Ltd.,
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中尾 英雄
Sankyo Research Laboratories Sankyo Co. Ltd.
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相馬 信夫
Central Research Laboratories Sankyo Co. Ltd.
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