Studies on Seven-membered Ring Compounds. XXXV. Ring Closure of γ-Cycloheptatrienyl-substituted α, β-Unsaturated Carbonyl Compounds to Benzocycloheptene Derivatives
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概要
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Ring closure reactions of γ-cycloheptatrienyl-substituted α, β-unsaturated carbonyl compounds by acid were examined. Treatment of 2-methyl-4- (2,4,6-cycloheptatrien-4-yl) -2-pentenal (II) with hydrobromic acid at room temperature in acetic acid afforded 1,3-dimethyl- (III) and 2,4-dimethyl-5H-benzocycloheptene (IV) accompanied by the production of 1,3,8-trimethylnaphthalene (V). On the ring closure of 5- (2,4,6-cycloheptatrien-4-yl) -3-hexen-2-one (VIII) by a similar procedure, 1,4-dimethyl-5H-benzocycloheptene (IX), 1,4,5-trimethylnaphthalene (X), and 1,4,6-trimethylnaphthalene (XI) were isolated.
- 社団法人日本薬学会の論文
- 1970-10-25
著者
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渡辺 泰一郎
Chemical Research Laboratories Sankyo Co. Ltd.
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相馬 信夫
Central Research Laboratories, Sankyo Co., Ltd.
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渡辺 泰一郎
Central Research Laboratories, Sankyo Co., Ltd.
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川本 勲
Central Research Laboratories, Sankyo Co., Ltd.
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川本 勲
Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.
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相馬 信夫
Central Research Laboratories Sankyo Co. Ltd.
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