Synthesis of α-Amino-cycloheptatriene-1-acetic Acids and Their 7-Acylaminocephalosporin Derivatives
スポンサーリンク
概要
- 論文の詳細を見る
tert-Butyl α-amino-2,4,6-cycloheptatriene-1-acetate (6) was prepared by treatment of tert-butyl N-benzylideneglycinate (5) with n-butyllithium followed by reaction with tropylium tetrafluoroborate. Heating 6 in xylene resulted in isomerization to tert-butyl α-amino-1,3,6-cycloheptatriene-1-acetate (7). Both the glycine derivatives were utilized for the acylation of a 7-amino-3-deacetoxycephalosporanic acid (7-ADCA) derivative (10) to obtain the orally active acyl derivative (14).
- 社団法人日本薬学会の論文
- 1982-07-25
著者
-
渡辺 泰一郎
Chemical Research Laboratories Sankyo Co. Ltd.
-
菅原 真一
Chemical Research Laboratories, Sankyo Co., Ltd.
-
宮寺 哲男
Chemical Research Laboratories, Sankyo Co., Ltd.
-
宮寺 哲男
Chemical Research Laboratories Sankyo Co. Ltd.
-
菅原 真一
Research Institute:sankyo Co. Ltd.
関連論文
- Quantitative Structure-activity Relationships in Minor Tranquilizers Benzodiazepinooxazole Derivatives
- Uber Tetrodotoxin. VI. Mitteilung. 2-Amino-6-methylchinazolin als Abbauprodukt von Tetrodotoxin.
- Uber Tetrodotoxin. Mitteilung. Synthese des C_9-Base-methylathers.
- Uber Tetrodotoxin. IV. Mitteilung. Die Struktur der C_9-Base, die sich durch Einwirkung der Alkalilauge auf Tetrodotoxin gewinnen la■t.
- 6.テトロドトキシンの構造研究
- Uber die Struktur der C_9-Base, die sich durch Behandlung mit Alkalilauge aus Tetrodotoxin gewinnen laβt
- Studies on Seven-membered Ring Compounds. XXIII. Reactions of Tropylium Ions Having Fused Heterocyclic System with Various Amines
- Studies on Seven-membered Ring Compounds. XXII. Preparation of Tropylium Ions Having Fused Heterocyclic Systems
- Studies on Seven-membered Ring Compounds. XIX. Reactions of Troponeimine Derivatives. (1)
- Studies on Seven-membered Ring Compounds. XV. Preparations of Troponeimine Derivatives
- Synthesis of α-Amino-cycloheptatriene-1-acetic Acids and Their 7-Acylaminocephalosporin Derivatives
- Synthesis of Amino Acid and 4,5-Dihydro-6H-1,3-thiazine Derivatives for the Preparation of Cephalosporin Compounds
- 3-Trifluoromethylcephalosporins. II. Synthesis and in Vitro Antibacterial Activities of 3-Trifluoromethylcephalosporin Derivatives
- 3-Trifluoromethylcephalosporins. I. Total Synthesis of tert-Butyl (±)-7-Amino-3-trifluoromethyl-3-cephem-4-carboxylate
- Syntheses of Highly Antibacterial 3-Vinylcephalosporin Derivatives
- Studies on Anticoccidial Agents. VII. An Improved Synthesis of α^4-Norpyridoxol
- Studies on Seven-membered Ring Compounds. XXXVI. Synthesis of Azulene Derivatives by Ring Closure of β-Cycloheptatrienyl-substituted Carbonyl Compounds
- Studies on Seven-membered Ring Compounds. XXXV. Ring Closure of γ-Cycloheptatrienyl-substituted α, β-Unsaturated Carbonyl Compounds to Benzocycloheptene Derivatives
- Studies on Seven-membered Ring Compounds. XXXIV. Reactions between Tropylium Cation and Dienamines
- Studies on Seven-membered Ring Compounds. XXXIII. Reactions between Tropylium Cation and Enamines
- Reactions of Ethyl 2-(1-Indanylidene) cyanoacetate Anion with Alkylating Agents and Aldehydes
- Studies on Chemotherapeutic Agents. II. Synthesis and Antibacterial Activity of 5-Substituted-5,8-dihydro-8-oxopyrido [2,3-b]-pyrazine-7-carboxylic Acids
- Studies on Quinolizinium Salts. IX. Ring-Opening Reactions of Benzo [α]-and Benzo [c] quinolizinium Bromides with a Grignard Reagent and Geometrical Determinations of the Resultant Butadienes
- Reactions of Chlordiazepoxide and Diazepam N-Oxide with Dimethyl Acetylenedicarboxylate with Rearrangement to Quinoxaline Derivatives and X-Ray Analysis of a Resultant Tetracyclic Compound
- Studies on Benzodiazepinooxazoles. II. Crystal and Molecular Structure of 10-Bromo-2,3,5,6,7,11b-hexahydro-2-methyl-11b-phenylbenzo [6,7]-1,4-diazepino [5,4-b] oxazol-6-one, C_H_O_2N_2Br・C_2H_5OH
- Synthesis of a Tricyclic Benzodiazepine Derivative from Chlordiazepoxide and X-Ray Crystallographic Analysis of a Rearrangement Product, the Indolenine Derivative
- Reactions of 2-Piperidylacetohydrazides with Ethyl Acetoacetate or Acetylenic Acid Esters. Formation of 3,4-Dimethylpyrano-[2,3-c] pyrazol (6) ones and Perhydropyrazolo [2,3-a]-pyrido [1,2-c] pyrimidin-2,5-diones
- Studies on Benzodiazepinooxazoles. V. Reactions of Benzo [6,7]-1,4-diazepino [5,4-b] oxazole Derivatives with Acetic Anhydride
- Studies on Benzodiazepinooxazoles. IV. The Formation of Quinolones by the Ring Contraction of a Benzo [6,7]-1,4-diazepino [5,4-b]-oxazole Derivative
- Studies on Benzodiazepinooxazoles. III. Reactions and Rearrangements of Benzo [6,7]-1,4-diazepino-[5,4-b] oxazole Derivatives
- Syntheses of 2-Hydroxymethylnicotinic Acid Lactone, 2-Hydroxymethylpyridine-3-acetic Acid Lactone, and Some of their Derivatives
- From Penicillin to Penem and Carbapenem. VII. : Synthesis and Antibacterial Activity of Penem Derivatives
- The Studies on Quinolizinium Salts. II. Ring Opening Reactions of Quinolizinium Bromide by Grignard Reagents
- The Studies on Quinolizinium Salts. I. Syntheses of Quinolizinium and 1-, 2-, 3-, and 4-Methylquinolizinium Bromides
- Studies on Quinolizinium Salts. III. Ring Opening Reactions of Monomethylquinolizinium Bromides by Phenylmagnesium Bromide