Studies on Quinolizinium Salts. III. Ring Opening Reactions of Monomethylquinolizinium Bromides by Phenylmagnesium Bromide
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概要
- 論文の詳細を見る
All four monomethylquinolizinium bromides were submitted to Grignard reactions using phenylmagnesium bromide in order to examine the substituent-effects on the ring opening reactions. The reaction of 1-and 3-methyl derivatives (IV, IX) gave exclusively disubstituted pyridines (V and X, XI) respectively and the 2-methyl derivative (XIV), 2-mono-(XV, XVII) and 2,4-disubstituted pyridines (XVI, XVIII) in almost equal ratio. These results were comparable to the substituent-effects of methylnaphthalenes. In the case of 4-methyl derivative (XXI) 2,6-disubstituted pyridine (XXII) was exclusively obtained probably owing to the steric hindrance at C_4-position of XXI.
- 公益社団法人日本薬学会の論文
- 1965-04-25
著者
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宮寺 哲男
Chemical Research Laboratories, Sankyo Co., Ltd.
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宮寺 哲男
Chemical Research Laboratories Sankyo Co. Ltd.
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宮寺 哲男
Research Laboratories, Sankyo Co., Ltd.
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