Studies on Benzodiazepinooxazoles. III. Reactions and Rearrangements of Benzo [6,7]-1,4-diazepino-[5,4-b] oxazole Derivatives

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概要

• 論文の詳細を見る

• Treatment of 10-halogeno-2,3,5,6,7,11b-hexahydro-7-methyl-11b-pheny1benzo [6,7]-1,4-diazepino [5,4-b] oxazol-6-one (IIIa-d) with dimethyl formamide in the presence of sodium hydride gave exo-methylene compounds (Va-d). On the other hand, the compounds (IIIe-g) having halogen at o-position of the 11b-phenyl group gave no exo-methylene compounds, but isoindoles (XVIIIe-g) and acridanone derivatives (XIXe-g). A mechanistic assumption for the formation of these compounds from benzo [6,7]-1,4-diazepino [5,4-b] oxazole derivatives was given.

• 公益社団法人日本薬学会の論文
• 1973-04-25

著者

• 宮寺 哲男

  Central Research Laboratories, Sankyo Co., Ltd.

• 太刀川 隆治

  Central Research Laboratories, Sankyo Co., Ltd.

• 太刀川 隆治

  Central Research Laboratories Sankyo Co. Ltd.

• 宮寺 哲男

  Chemical Research Laboratories, Sankyo Co., Ltd.

• 寺田 敦祐

  Central Research Laboratories, Sankyo Co., Ltd.

• 寺田 敦祐

  京都薬科大学 化学研究所

• 矢部 裕一郎

  Central Research Laboratories, Sankyo Co., Ltd.

• 宮寺 哲男

  Chemical Research Laboratories Sankyo Co. Ltd.

• 矢部 裕一郎

  Exploratory Chemistry Research Sankyo Co. Ltd.

• Terada A

  Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.

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