Studies on 1,3-Benzoxazines. VII. Formation of Diphenylpyrimidines by the Reaction of 4-Chloro-2H-1,3-benzoxazines with Ethyl 3-Aminobutyrate
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概要
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A new reaction mode for the formation of pyrimidine derivatives by the reaction of 4-chloro-2H-1,3-benzoxazines (1a-f) with ethyl 3-aminobutyrate is described. Treatment of chlorobenzoxazines (1a-f) with ethyl 3-aminobutyrate (2) gave pyrimidine derivatives (4a-f) possessing an o-hydroxyphenyl substituent. When 4-chloro-2-methyl-2-methoxycarbonylmethyl-2H-1,3-benzoxazine (1g) was treated with 2,a pyrimidinone derivative (7) was isolated. A possible mechanism for the formation of these reaction products is discussed.
- 公益社団法人日本薬学会の論文
- 1982-02-25
著者
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太刀川 隆治
Central Research Laboratories, Sankyo Co., Ltd.
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太刀川 隆治
Central Research Laboratories Sankyo Co. Ltd.
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寺田 敦祐
Central Research Laboratories, Sankyo Co., Ltd.
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和智 一之
京都薬科大学 化学研究所
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寺田 敦祐
京都薬科大学 化学研究所
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和智 一之
Central Research Laboratories, Sankyo Co., Ltd.
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Terada A
Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.
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