Studies on 1,3-Benzoxazines. I. Synthesis of Primary 2-Aminopyridines via the Reaction of Imidoyl Chlorides of 1,3-Benzoxazines with Pyridine N-Oxides
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概要
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A new synthetic method for primary 2-aminopyridine derivatives is described. Treatment of the imidoyl chlorides of 1,3-benzoxazines (1a-i) with pyridine N-oxides resulted in the introduction of an oxazine moiety into the α-position of the pyridine ring through rearrangement of the initially formed reaction adduct. Acid hydrolysis of the rearrangement products afforded 2-aminopyridine derivatives in excellent yields. When methoxypyridine N-oxides were used, products of a different type (10 and 14) were obtained.
- 公益社団法人日本薬学会の論文
- 1980-02-25
著者
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寺田 敦祐
Central Research Laboratories, Sankyo Co., Ltd.
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和智 一之
京都薬科大学 化学研究所
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寺田 敦祐
京都薬科大学 化学研究所
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和智 一之
Central Research Laboratories, Sankyo Co., Ltd.
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Terada A
Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.
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