Optical Resolution and Determination of Absolute Configuration of (±)-2-[4-(2-Oxocyclopentylmethyl) phenyl] propionic Acids
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概要
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The title compound, which was newly synthesized, showed good anti-inflammatory and analgesic activities. Optical resolution was performed by the following procedures : 1) condensation of the acid with (-)-1-phenylethylamine followed by separation of diasteromeric amides ; 2) reduction of the cyclopentanone moiety and then acylation with optically active acid ; 3) separation of epimeric esters followed by saponification of esters ; 4) oxidation of alcohols to ketones ; 5) saponification of amides. The absolute configurations of the four optically active compounds thus obtained were confirmed by circular dichroism spectroscopy.
- 公益社団法人日本薬学会の論文
- 1983-12-25
著者
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寺田 敦祐
京都薬科大学 化学研究所
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成戸 俊二
Chemical Research Laboratories Sankyo Co., Ltd.
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成戸 俊二
三共
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寺田 敦祐
Chemical Research Laboratories, Sankyo Co., Ltd.
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Terada A
Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.
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