Studies on 1,3-Benzoxazines. III. Reaction of Imidoyl Chlorides of 1,3-Benzoxazines with 2-Hydroxy- or 2-Mercaptopyridine N-Oxides : A Novel S-N Bond Formation via Electrocyclic Rearrangement
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概要
- 論文の詳細を見る
A novel S-N bond formation through 3,3-sigmatropic rearrangement in the reaction of imidoyl chlorides of 1,3-benzoxazines (1) with 2-mercaptopyridine N-oxide (8) is described. Treatment of the imidoyl chlorides (1a-f) with 2-hydroxypyridine N-oxide (2) afforded the corresponding pyridone derivatives (3a-f). When 2-mercaptopyridine N-oxide (8) was used instead of 2,the thiopyridones (7) or N-oxides (9) were obtained and both compounds were transformed to 3-(2-pyridylthio)-4-oxo-2,3-dihydro-1,3-benzoxazines (13) through electrocyclic rearrangement on heating in a suitable solvent.
- 公益社団法人日本薬学会の論文
- 1981-12-25
著者
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佐藤 定男
Analytical And Metabolic Research Laboratories:sankyo Co. Ltd.
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佐藤 定男
Central Research Laboratories, Sankyo Co., Ltd.
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寺田 敦祐
Central Research Laboratories, Sankyo Co., Ltd.
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和智 一之
京都薬科大学 化学研究所
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寺田 敦祐
京都薬科大学 化学研究所
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太刀川 隆次
Central Research Laboratories, Sankyo Co., Ltd.
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和智 一之
Central Research Laboratories, Sankyo Co., Ltd.
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太刀川 隆次
Central Research Laboratories Sankyo Co. Ltd.
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Terada A
Medicinal Chemistry Research Laboratories Sankyo Co. Ltd.
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