Asymmetric Transformation. III. : Crystal Properties and Structures of a 1,4-Benzodiazepinooxazole Derivative
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概要
- 論文の詳細を見る
Three forms of crystals, the optically active α-form and the optically inactive β-and γ-forms, of 10-bromo-11b-(2-fluorophenyl)-2,3,7,11b-tetrahydrooxazolo[3,2-d][1,4]benzodiazepin-6(5H)-one (1) were obtained by different crystallization procedures. The α-form crystal was estimated to be the most stable and the least soluble crystal among them by comparison of the thermodynamic properties of these crystals and the mutual transformations among these crystal forms. X-Ray analyses elucidated that the α-form crystal was an enatiomer, and the β- and γ-form crystals were racemates. Consequently, if a suitable crystallizing condition is selected, it is possible for compound 1 to crystallize as more stable and less soluble crystals of one enantiomer (prior to crystallization of racemates) from methanol solution. These crystal properties of 1 are essential for the second-order asymmetric transformation to occur.
- 公益社団法人日本薬学会の論文
- 1989-01-25
著者
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佐藤 定男
Analytical and Metabolic Research Laboratories, Sankyo Co., Ltd.,
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佐藤 定男
Analytical And Metabolic Research Laboratories:sankyo Co. Ltd.
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佐藤 定男
Analytical And Metabolic Research Laboratories Sankyo Co. Ltd.
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岡田 泰
Process Development Laboratories Sankyo Co. Ltd.
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竹林 [トヨ]矩
Process Development Laboratories, Sankyo Co., Ltd.,
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竹林 矩
Process Development Laboratories Sankyo Co. Ltd.
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