Asymmetric Transfomation. II. : Racemization Reaction of 1,4-Benzodiazepinoxazole Derivative

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概要

• 論文の詳細を見る

• Optically active crystals of 10-bromo-11b-(2-fluorophenyl)-2,3,7,11b-tetrahydrooxazolo-[3,2-d][1,4]denzodiazepin-6(5H)-one were obtained by preferential crystallization; they were sometimes levorotary and sometimes dextrorotatory. This phenomenon was proved to be an example of second-order asymmetric transformation between enantiomers. The rapid recemization reaction, which was essential for asymmetric transformation, was observed in methanol. The decrease of optical rotation obeyed good pseudo first-order kinetics and the half-lives of the racemization in methanol were estimated to be about 21 s at 30℃, 37s at 20℃ and 70s at 10℃. The mechanism and factors which affect the rate of the recemization are discussed.

• 公益社団法人日本薬学会の論文
• 1988-10-25

著者

• 岡田 泰

  Process Development Laboratories Sankyo Co. Ltd.

• 竹林 潔矩

  Process Development Laboratories, Sankyo Co., Ltd.,

• 竹林 潔矩

  Process Development Laboratories Sankyo Co. Ltd.

関連論文

• Stereo-chemistry of Steroids Containing Aromatic A-Ring. III. Hydrogenation of 11β-Hydroxy-⊿^8-dehydroestrone.
• Stereochemistry of Steroid containing Aromatic A-Ring. I. Reaction of 9 (11)-Dehydroestrone.
• Asymmetric Transformation. III. : Crystal Properties and Structures of a 1,4-Benzodiazepinooxazole Derivative
• Asymmetric Transfomation. II. : Racemization Reaction of 1,4-Benzodiazepinoxazole Derivative
• Syntheses and Properties of Formyl Sarcosine^1-LH-RH and N-Methyl-L-pGlu^1-LH-RH
• Bromo Derivative of Cholestadienone.

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