Isolation of Three New Sesquiterpene Lactones from the Pericarps of Illicium majus

概要

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Three new sesquiterpene lactones, majucin (3), neomajucin (4), and 2,3-dehydroneomajucin (5), have been isolated from the pericarps of Chineses Illicium majus, which is a toxic plant. The spectral features of compounds 3 and 4 were similar to those of anisatin (1), a convulsant from Japanese star anise. The structure of neomajucin (4) was determined by an X-ray crystallographic analysis, and the structures of the other compounds were deduced from the ^1H- and ^<13>C-nuclear magnetic resonance spectral data, aided by an extensive analysis of the ^1H-^1H, ^<13>C-^1H, and ^<13>H-^1H long-range two dimensional shift-correlated spectra, on the basis of the structure of neomajucin. Only neomajucin exhibited picrotoxin-like toxicity, amounting to one-tenth of that of anisatin.
社団法人日本薬学会の論文
1989-09-25