Amino Acids and Peptides. IX. : Synthetic Studies on Leu-Enkephalin Analogues Containing a Ureylene Bond
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概要
- 論文の詳細を見る
Leu-enkephalin analogues containing a ureylene bond instead of an amide bond were synthesized. The ureylene bond was formed by a coupling reaction of the isocyanate derived from the corresponding azide by Curtius rearrangement reaction. Three analogues, each of which has a ureylene bond at the Tyr-Gly or Gly-Gly or Phe-Leu amide bond, were prepared. The ureylene bond resisted enzymatic hydrolysis, but the biological activities of the synthetic peptides on guinea pig ileum and mouse was deferens were low compared with those of Leu-enkephalin.
- 社団法人日本薬学会の論文
- 1988-05-25
著者
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川崎 紘一
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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前田 光子
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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金戸 洋
長崎大学薬学部薬物学教室
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Maeda M
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University:faculty Of Pharmac
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渡辺 穰
Japan and Faculty of Pharmaceutical Sciences, Nagasaki University
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金戸 洋
Japan and Faculty of Pharmaceutical Sciences, Nagasaki University
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渡辺 穣
神戸学院大学 薬
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渡辺 穰
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University
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Kawasaki Keiko
Biological Science Laboratories Kao Corporation
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川崎 紘一
Faculty Of Pharmaceutical Sciences & Cooperative Research Center Of Life Sciences Kobe Gakuin Un
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Maeda Masatomo
Laboratory Of Biochemistry And Molecular Biology Graduate School Of Pharmaceutical Sciences Osaka Un
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