Amino Acids and Peptides. XXII. Preparation and Antinociceptive Effect of [D-Ala^2] Leu-Enkephalin-Poly (Ethylene Glycol) Hybrid
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概要
- 論文の詳細を見る
The hybrid of poly (ethylene glycol) and [D-Ala^2] Leu-enkephalin was prepared by the solution method and its antinociceptive effect and inhibitory effect on the electrically induced contractions of mouse vas deferens were examined. The hybrid was synthesized by the coupling of Boc-Tyr-D-Ala-Gly-Phe-Leu-OH and amino-poly (ethylene glycol), followed by trifluoroacetic acid treatment. The hybrid showed more potent antinociceptive activity in mice and 120 times higher inhibitory activity in mouse vas deferens preparation than intact [D-Ala^2] Leu-enkephalin.
- 社団法人日本薬学会の論文
- 1994-06-15
著者
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真弓 忠範
Faculty of Pharmaceutical Sciences
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川崎 紘一
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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前田 光子
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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金戸 洋
長崎大学薬学部薬物学教室
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高橋 正克
Faculty of Pharmaceutical Sciences, Nagasaki University
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金戸 洋
Faculty of Pharmaceutical Sciences, Nagasaki University
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高橋 正克
長崎大学薬学部医療情報・分析学教室
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前田 光子
Life Science Center Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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金戸 洋
Faculty Of Pharmaceutical Sciences Nagasaki University 1-14 Bunkyocho Nagasaki
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川崎 紘一
Life Science Center Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Maeda M
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University:faculty Of Pharmac
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Kawasaki Keiko
Biological Science Laboratories Kao Corporation
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川崎 紘一
Faculty Of Pharmaceutical Sciences & Cooperative Research Center Of Life Sciences Kobe Gakuin Un
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Maeda Masatomo
Laboratory Of Biochemistry And Molecular Biology Graduate School Of Pharmaceutical Sciences Osaka Un
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