Amino Acids and Peptides. XVII. Synthesis of Peptides Related to N-Terminal Portion of Fibrin α-Chain and Their Inhibitory Effect on Fibrinogen : Thrombin Clotting

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概要

• 論文の詳細を見る

• Various peptides related to N-terminal portion of fibrin α-chain were synthesized by the solution method and the solid-phase method, and their inhibitory effect on fibrinogen/thrombin clotting was examined. Extension of peptide chain from N-terminal tripeptid decreased the inhibitory effect. The most potent effect was shown by N-terminal decapeptide analog, H-Gly-Pro-Arg-Pro-Pro-Glu-Arg-His-Gln-Ser-NH_2.

• 社団法人日本薬学会の論文
• 1993-03-15

著者

• 川崎 紘一

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• 井上 幸江

  Faculty Of Pharmaceutical Sciences Kobe-gakuin University

• 辻 俊樹

  Faculty of Pharmaceutical Sciences, Kobe-Gakuin University

• 平瀬 克彦

  Faculty of Pharmaceutical Sciences, Kobe-Gakuin University

• 宮野 雅範

  Faculty of Pharmaceutical Sciences, Kobe-Gakuin University

• 岩本 雅広

  Research Institute, Daiichi Seiyaku Co., Ltd.,

• 岩本 雅博

  Research Institute Daiichi Seiyaku Co. Ltd.

• 岩本 政博

  Research Institute Daiichi Seiyaku Co.. Ltd.

• 辻 俊樹

  Faculty Of Pharmaceutical Sciences Kobe-gakuin University

• 宮野 雅範

  Faculty Of Pharmaceutical Sciences Kobe-gakuin University

• 平瀬 克彦

  Faculty Of Pharmaceutical Sciences Kobe-gakuin University

• Kawasaki Keiko

  Biological Science Laboratories Kao Corporation

• 川崎 紘一

  Faculty Of Pharmaceutical Sciences & Cooperative Research Center Of Life Sciences Kobe Gakuin Un

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