Studies on Peptides. IX. Synthesis of N-(Histidylphenylalanylarginy1)-5-methoxytryptamine, an Inhibitor of α-Melanocyte-stimulating Hormone in virto
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概要
- 論文の詳細を見る
The N-acetyl group of melatonin was replaced with a histidylphenylalanylarginyl moiety . The product , N-(histidyenylalanylarginy1)-5-methoxytryptamine, reversed the darkening action of α-melanocyte-stimulating hormone (MSH) on frog-skin in vitro in contrast to the closely related tetrapeptide, histidylphenylalanylarginyltryptophan which exhibits intrinsic MSH activity. The synthetic intermediates, N-arginy1-5-meth-oxytryptamine and N-(phenylalanylarginyl)-5-methoxytryptamine also reversed the action of α-MSH. The color lightening potency of these compounds was about one millionth that of melatonin.
- 公益社団法人日本薬学会の論文
- 1966-08-25
著者
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小井田 雅夫
Faculty Of Pharmaceutical Science Osaka University
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小井田 雅夫
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Setsunan University
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矢島 治明
Faculty Of Pharmaceutical Sciences Kyoto University
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Kawasaki Keiko
Biological Science Laboratories Kao Corporation
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川崎 紘一
Faculty Of Pharmaceutical Sciences & Cooperative Research Center Of Life Sciences Kobe Gakuin Un
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- Studies on Peptides. IX. Synthesis of N-(Histidylphenylalanylarginy1)-5-methoxytryptamine, an Inhibitor of α-Melanocyte-stimulating Hormone in virto