Amino Acids and Peptides. XXVII. Solid Phase Synthesis of Fibrinogen-Related Peptides with Disulfide Bond Formed on Solid Support
スポンサーリンク
概要
- 論文の詳細を見る
Fibrinogen-related peptides, monomeric cyclic peptides through a disulfide bond [cyclo(H-Cys-Arg-Gly-Asp-Phe-Cys-NH_2), cyclo(H-Cys-Arg-Gly-Asp-Phe-Cys-Gly-NH_2), cyclo(H-Cys-Arg-Gly-Asp-Cys-NH_2) and cyclo(H-Cys-Arg-Gly-Asp-Cys-Gly-NH_2)], were prepared by the solid phase method with disulfide bond formation on the solid support. The acetamidomethyl group was used for protection of the thiol group of Cys and synthetic peptide-resins were treated with iodine to give the disulfide bond. Monomeric cyclic peptides were obtained as main products. Purified S-acetamidomethylated peptides were also oxidized with iodine, but the desired materials could not be isolated by HPLC. The disulfide formation from S-acetamidomethylcystein-containing peptide resin by iodine treatment on the solid support was more effective than that from S-acetamidomethylcysteine-containing peptide. The inhibitory effects of the cyclic peptides on platelet aggregation were much more potent than that of H-Arg-Gly-Asp-NH_2.
- 公益社団法人日本薬学会の論文
- 1996-05-15
著者
-
前田 光子
Life Science Center Faculty Of Pharmaceutical Sciences Kobe Gakuin University
-
川崎 紘一
Life Science Center Faculty Of Pharmaceutical Sciences Kobe Gakuin University
-
Maeda M
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University:faculty Of Pharmac
-
Maeda Mitsuko
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
-
KAWASAKI Koichi
Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University
-
FUJIWARA Kunio
Faculty of Pharmaceutical Sciences, Nagasaki University
-
UEDA Kaori
Faculty of Pharmaceutical Sciences, Kobegakuin University
-
IZUNO Yasuhiro
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
-
垣内 正人
Research And Development Division Hokuriku Seiyaku Co. Ltd
-
KAKIUCHI Masa
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
-
FUJIWARA Kazuko
Exploratory Research Laboratories II, Daiichi Pharmaceutical Co., Ltd.,
-
KUNITADA Satoshi
Exploratory Research Laboratories II, Daiichi Pharmaceutical Co., Ltd.,
-
Izuno Yasuhiro
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
-
Fujiwara K
Faculty Of Pharmaceutical Sciences Nagasaki University
-
Ueda K
Faculty Of Pharmaceutical Sciences Kobegakuin University
-
Kawasaki Keiko
Biological Science Laboratories Kao Corporation
-
Kakiuchi M
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
-
Fujiwara Kunio
Faculty Of Pharmaceutical Sciences Nagasaki University
-
Maeda Masatomo
Laboratory Of Biochemistry And Molecular Biology Graduate School Of Pharmaceutical Sciences Osaka Un
-
Kunitada Satoshi
Exploratory Research Laboratories Ii Daiichi Pharmaceutical Co. Ltd.
関連論文
- Amino Acids and Peptides. XXVI. Laminin-Related Peptide Poly (Ethylene Glycol) Hybrids and Their Inhibitory Effect on Experimental Metastasis
- Amino Acids and Peptides. XXV. Preparation of Fibronectin-Related Peptide Poly(ethylene glycol) Hybrids and Their Inhibitory Effect on Experimental Metastasis
- Cell-Penetrating Peptides as Adenovirus Vector Carrier
- Amino Acids and Peptides. XXI. Laminin-Related Peptide Analogs Including Poly(Ethylene Glycol) Hybrids and Their Inhibitory Effect on Experimental Metastasis
- PREPARATION OF [ARG-GLY-ASP]-[AMINO-POLY(ETHYLENE GLYCOL)] HYBRIDS AND THEIR INHIBITORY EFFECT ON EXPERIMENTAL METASTASIS
- Amino Acids and Peptides. XXIV. Preparation and Antinociceptive Effect of [D-Ala^2,(N-Me)Phe^4]Enkephalin Analog-Poly(Ethylene Glycol)Hybrids
- Amino Acids and Peptides. XXIII. Leu-Enkephalin Analogs Containing a Fluorinated Amino Acid at Position 2,4 or 5
- Human Chorionic Gonadotropin. VII. Preparation and Immunocharacteristics of Carboxyl-terminal Peptides of the β-Subunit of Human Chorionic Gonadotropin
- Human Chorionic Gonadotropin. VI. Synthesis of a Tetratriacontapeptide corresponding to the C-Terminal Sequence 112-145 of the β-Subunit of Human Chorionic Gonadotropin (hCG)
- Human Chorionic Gonadotropin. V. Synthesis of a Triacontapeptide corresponding to the C-Terminal Sequence 116-145 of the β-Subunit of Human Chorionic Gonadotropin (hCG)
- Human Chorionic Gonadotropin. IV. Synthesis of a Hexadecapeptide corresponding to the C-Terminal Sequence 130-145 of the β-Subunit of Human Chorionic Gonadotropin (hCG)
- Human Chorionic Gonadotropin. III. Synthesis of a Dotriacontapeptide corresponding to the C-Terminal Sequence 116-147 of the β-Subunit of Human Chorionic Gonadotropin (hCG)
- Human Chorionic Gonadotropin. II. Synthesis of a Hexadecapeptide corresponding to the C-Terminal Sequence 132-147 of the β-Subunit of Human Chorionic Gonadotropin (hCG)
- Synthesis of C-Terminal Peptides of the β-Subunit of Human Chorionic Gonadotropin (hCG)
- 生理活性ペプチドの高分子ハイブリッド化 DDS - ポリスチレンマレイン酸によるラミニン関連細胞接着ペプチドのバイオコンジュゲーションとその癌転移抑制効果 -
- Amino Acids and Peptides. XXII. Preparation and Antinociceptive Effect of [D-Ala^2] Leu-Enkephalin-Poly (Ethylene Glycol) Hybrid
- Amino Acids and Peptides. XIX. Preparation of Enkephalin-Poly(ethylene glycol) Hybrid and Evaluation of Its Analgesic Activity
- Amino Acids and Peptides. XVII. Synthesis of Peptides Related to N-Terminal Portion of Fibrin α-Chain and Their Inhibitory Effect on Fibrinogen : Thrombin Clotting
- Synthesis of a Tetradecapeptide corresponding to Sequence 90-103 of Bovine Adrenodoxin
- Amino Acids and Peptides. I. Synthesis of a Model Peptide related to Iron-Sulfur Protein
- Synthesis of Two Heptapeptides corresponding to Sequences 50-56 and 90-96 of Adrenodoxin from Bovine Adrenal Cortex and Formation of Their Iron-Sulfur Complexes
- Studies on Peptides. XVI. Regeneration of Lysine from N^ε-Formyllysine by Aqueous Hydrazine or Hydroxylamine and Their Application to the Synthesis of α-Melanocyte-stimulating Hormone
- P1-582 模擬患者を活用した初年次教育の実践とその教育的成果(一般演題 ポスター発表,薬学教育(その他),臨床から学び臨床へと還元する医療薬学)
- Preparation and Biological Activities of a Bivalent Poly(Ethylene Glycol) Hybrid Containing an Active Site and Its Synergistic Site of Fibronectin
- Synthesis of a Tetradecapeptide corresponding to Sequence 50-63 of Adrenodoxin from Bovine Adrenal Cortex and Formation of Its Iron-Sulfur Complex
- Facile Conversions of Carboxylic Acids into Amides, Esters, and Thioesters Using 1,1'-Oxalyldiimidazole and 1,1'-Oxalyldi(1,2,4-triazole)(Organic,Chemical)
- Amino Acids and Peptides. X. : Leu-Enkephalin Analogues Containing a Fluorinated Aromatic Amino Acid
- Amino Acids and Peptides. IX. : Synthetic Studies on Leu-Enkephalin Analogues Containing a Ureylene Bond
- Enzyme Immunoassay for a Characteristic Protein in the Animal Crude Drug Lumbricus
- Application of a Licorice Root Specific Protein to a General Method for the Assay of Licorice Root Components in Traditional Chinese Medicines
- Amino Acids and Peptides. VII. : Preparation and Application of a Water-Soluble Active Ester, p-Trimethylammoniophenyl Ester
- Amino Acids and Peptides. IV. Synthesis and Analgesic Effects of Tyr-Containing Dipeptide Phenethylamides
- The Effect of Tulobuterol Tape on Histamine-Induced Bronchoconstriction in Conscious Guinea Pigs:Long Duration of Action
- Central Nervous System Effects of the Novel Antiallergic Agent HSR-609 and Typical Antiallergic Agents Using Behavioral and Electroencephalographic Analyses in Dogs
- Pharmacological Studies on the Novel Antiallergic Agent HSR-609: Its Effects on Behavior in Mice and Electroencephalograms in Rabbits
- Studies on the Novel Antiallergic Agent HSR-609:Its Penetration into the Central Nervous System in Mice and Guinea Pigs and Its Selectivity for the Histamine H]-Receptor
- Effects of α-Linolenic Acid-rich Diacylglycerol on Diet-induced Obesity in Mice
- Effects of Tea Catechins on Diet-induced Obesity in Mice〔和文〕
- Enhancing Effect of α-Monoisostearyl Glyceryl Ether on the Percutaneous Penetration of Indomethacin through Excised Rat Skin
- Studies on Heterobifunctional Cross-Linking Reagents, 6-Maleimidohexanoic Acid Active Esters
- "Solid Phase Synthesis in Water" Using Fmoc-Amino Acid Nanoparticles
- Evolution Towards A Clinical Pharmacy Degree Program : A U.S. Perspective
- An Update on Community Pharmacy Practice in the United States
- Amino Acids and Peptides.XXXVIII.Facile Synthesis of Laminin-Related Peptide-Poly(Ethylene Glycol)Hybrids by the Solid Phase Method
- Conjugation of a Laminin-Related Antimetastatic Peptide with Chitosan (Part 3)
- Mechanism of Liver Tyrosine Aminotransferase Increase in Ethanol-Treated Mice and Its Effect on Serum Tyrosine Level
- Effect of Fasting on Methionine Adenosyltransferase Expression and the Methionine Cycle in the Mouse Liver
- 29-P3-73 アメリカ薬学研修への新たな取り組み(No.2)(薬学教育,社会の期待に応える医療薬学を)
- Synthesis of Peptide Mimetics That Related to Tethered Thrombin Receptor and Their Agonist/Antagonist Activities on Platelet Aggregation
- Evaluation of a New N-Protecting Group, 2-(4-Sulfophenylsulfonyl)ethoxycarbonyl Group, for Solid Phase Peptide Synthesis in Water
- Peptide Synthesis in Water IV. Preparation of N-Ethanesulfonylethoxycarbonyl (Esc) Amino Acids and Their Application to Solid Phase Peptide Synthesis
- Solid Phase Synthesis in Water : Application of the Ethanesulfonylethoxycaronyl (Esc) Group
- Improved Preparation of an Amino Acid Type Poly(Ethylene Glycol) Derivative
- A New N-Protecting Group, 2-[Phenyl(methyl)sulfonio]ethyloxycarbonyl Tetrafluoroborate, and Its Application to Solid Phase Peptide Synthesis in Water
- Acylation of Hydrazides with Acetic Acid and Formic Acid
- 教育賞受賞 濱 堯夫氏の業績
- A Bivalent Poly (ethylene glycol) Hybrid Containing an Active Site (RGD) and a Synergistic Site of Fibronectin
- Amino Acids and Peptides. XXXV. Facile Preparation of p-Nitroanilide Analogs by the Solid-Phase Method
- A Facile Solid-Phase Synthesis of Peptide ρ-Nitroanilide Analogs
- Regioselective Conjugation of Chitosan with a Laminin-related Peptide, Tyr-Ile-Gly-Ser-Arg, and Evaluation of Its Inhibitory Effect on Experimental Cancer Metastasis
- Synthesis of Some Pseudo-Peptide Analogs of Thiol Proteinase Inhibitors
- Amino Acids and Peptides. VIII. : A Water-Soluble Active Ester, Phenolsulfonic Acid Derivative(Organic,Chemical)
- A General Enzyme Immunoassay for the licorice Root Component Contained in Traditional Chinese Medicines
- A New Method for the Detection and Quantitative Measurement of the Contents of Trichosanthes Root Component Composing Chinese Traditional Medicines
- Amino Acids and Peptides. XX. Preparation of β-Cyclododecyl Aspartate and Its Application to Synthesis of Fibronectin- and Laminin-Related Peptides
- Preparation of Laminin γ1 Chain Related Peptide Poly (Ethylene Glycol) Hybrid
- Amino Acids and Peptides. XXXI. Preparation of Analogs of the Laminin-Related Peptide YIGSR and Their Inhibitory Effect on Experimental Metastasis
- Amino Acids and Peptides. XXX. Preparation of Arg-Gly-Asp (RGD) Hybrids with Poly(Ethylene Glycol) Analogs and Their Antimetastatic Effect
- Amino Acids and Peptides. XXIX. Synthesis and Antimetastatic Effects of Peptides and Peptide-Poly(Ethylene Glycol) Hybrids Related to the Core Sequence of the Type III Connecting Segment Domain of Fibronectin
- Studies on Quinolone Antibacterials. V. Synthesis and Antibacterial Activity of Chiral 5-Amino-7-(4-substituted-3-amino-1-pyrrolidinyl)-6-fluoro-1,4-dihydro-8-methyl-4-oxoquinoline-3-carboxylic Acids and Derivatives
- Amino Acids and Peptides. XXVII. Solid Phase Synthesis of Fibrinogen-Related Peptides with Disulfide Bond Formed on Solid Support
- Studies on Quinolone Antibacterials. IV. Structure-Activity Relationships of Antibacterial Activity and Side Effects for 5- or 8-Substituted and 5,8-Disubstituted-7-(3-amino-1-pyrrolidinyl)-1-cycloporpyl-1,4-dihydro-4-oxoquinoline-3-carboxylic Acids
- Preparation of Laminin-related Peptide Analogs and Their Inhibitory Effect on Experimental Metastasis in Mice
- The Carboxyl Terminal Sequence of Rat Transporter Associated with Antigen Processing (TAP)-Like (ABCB9) is Heterogeneous due to Splicing of Its mRNA(Biochemistry/Molecular Biology)
- Total Synthesis of (-)-Bulgecinine
- Samarium(II) Iodide-Mediated Intermolecular Coupling Reactions of N, N-Dibenzylenamides with Carbonyl Compounds and Transformation of the Product, N, N-Dibenzyl-γ-hydroxyamide to δ-Aminoalcohol
- Medicinal Foodstuffs. XXXI. Structures of New Aromatic Constituents and Inhibitors of Degranulation in RBL-2H3 Cells from a Japanese Folk Medicine, the Stem Bark of Acer nikoense
- New Farnesane-Type Sesquiterpenes, Hedychiols A and B 8,9-Diacetate, and Inhibitors of Degranulation in RBL-2H3 Cells from the Rhizome of Hedychium coronarium
- Bioactive Constituents of Chinese Natural Medicines. VII.^ Inhibitors of Degranulation in RBL-2H3 Cells and Absolute Stereostructures of Three New Diarylheptanoid Glycosides from the Bark of myrica rubra
- Amino Acids and Peptides. V. Synthesis of Amino Acid Derivatives Containing a Sulfonamide Bond
- Amino Acids and Peptides. XXVIII. Preparation of Poly(Ethylene Glycol)Hybrids of Gln-Val-Val-Ala-Gly Analogs and Their Inhibitory Effect on Papain
- A New Reagent, 2-[Phenyl(methyl)sulfonio]ethyl-4-nitrophenylcarbonate Tetrafluoroborate (Pms-ONp), for Preparation of Water-Soluble N-protected Amino Acids
- Membrane Localization of Transporter Associated with Antigen Processing (TAP)-Like (ABCB9) Visualized in Vivo with a Fluorescence Protein-Fusion Technique(Biochemistry/Molecular Biology)
- A Half-Type ABC TRansporter TAPL Is Highly Conserved between Rodent and Man, and the Human Gene Is Not Responsive to Interferon-γ in Contrast to TAP1 and TAP2^1
- Structures of P-type Transporting ATPases and Chromosomal Locations of Their Genes
- Preparation of A Fibronectin-related Poly(Ethylene Glycol) Hybrid and Its Inhibitory Effect on Experimental Metastasis in Mice
- Glutaraldehyde (GA)-Hapten Adducts, but without a Carrier Protein, for Use in a Specificity Study on an Antibody against a GA-Conjugated Hapten Compound: Histamine Monoclonal Antibody (AHA-2) as a Model
- Amino Acids and Peptides. III. Synthesis of Model Peptides Related to Cytochrome P-450
- Preparation of Monoclonal Antibodies against N-(γ-Maleimidobutyryloxy)succinimide (GMBS)-Conjugated Acetylspermine,and Development of an Enzyme-Linked Immunosorbent Assay (ELISA) for N^1,N^-Diacetylspermine
- Development and Application of a Sandwich Enzyme Immunoassay for Glycyrrhizae Radix Protein (GRP) Using Monoclonal Antibodies
- Specificities of Five Kinds of Antisera Produced against Crude Drugs, Pinellia Tuber, Hoelen, Glycyrrhizae Radix, Trichosanthes Root and Panax Ginseng
- Determination of Urinary Acetylpolyanines by a Monclonal Antiboby-Based Enzyme-Linked Immunosorbent Assay (ELISA)
- Histamine Monoclonal Antibody for Brain Immunocytochemistry
- The Opioid Activity and Receptor Selectivity of Fluorinated Leu^5 Enkephalin Analogues in Vitro and in Vivo
- Selectivity for Opioid Receptor Subtypes of Enkephalin Analogues in Isolated Smooth Muscle and in the Analgesic Effect in Mice
- INVOLVEMENT OF DIFFERENT RECEPTOR SUBTYPES FOR THE PRODUCTION OF IN VITRO AND IN VIVO EFFECTS IN A SERIES OF SYNTHETIC ENKEPHALIN ANALOGUES
- Microwave Assisted Solid-Phase Peptide Synthesis in Water Using Water-Dispersible Fmoc-Amino Acid NanoParticles
- プリオンタンパク質の銅結合部位
- PYROGLUTAMYL PEPTIDASE FROM CHICKEN LIVER : PURIFICATION AND SOME PROPERTIES
- ラミニン由来ガン転移抑制ペプチドとキトサンとのハイブリッド体の調製