Bioactive Constituents of Chinese Natural Medicines. VII.^<1)> Inhibitors of Degranulation in RBL-2H3 Cells and Absolute Stereostructures of Three New Diarylheptanoid Glycosides from the Bark of myrica rubra
スポンサーリンク
概要
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Three new diarylheptanoid glycosides, named(+)-S-myricanol 5-0-β-D-glucopyranoside, myricanene A 5-O-α-L-arabinofuranosyl(1→6)-β-D-glucopyranoside, and myricanene B 5-O-α-L-arabinofuranosyl(1→6)-β-D-glucopyranoside, were isolated from the bark of Chinese Myrica rubra, together with twenty known compounds. The absolute stereostructures of the new diarylheptanoid glycosides were elucidated on the basis of chemical and physicochemical evidence, including the application of the modified Mosher's method. The inhibitory effects of isolated constituents on the release of β-hexosaminidase from RBL-2H3 cells were examined, and several diaryl-heptanoids, myricanol, (+)-S-myricanol, myricanoe, and myricanenes A and B, and a flavonol, myricetin, were found to show the inhibitory activity.
- 公益社団法人日本薬学会の論文
- 2002-02-01
著者
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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Morikawa Toshio
Kyoto Pharmaceutical University
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吉川 雅之
Kyoto Pharmaceutical Univ.
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Yamazaki M
School Of Pharmaceutical Sciences Kinki University
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TAO Jing
Kyoto Pharmaceutical University
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UEDA Kazuho
Kyoto Pharmaceutical University
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Ueda K
Faculty Of Pharmaceutical Sciences Kobegakuin University
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MATSUDA HISASHI
Kyoto College of Pharmacy
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