Amino Acids and Peptides. XIX. Preparation of Enkephalin-Poly(ethylene glycol) Hybrid and Evaluation of Its Analgesic Activity

スポンサーリンク

概要

• 論文の詳細を見る

• The poly(ethylene glycol) hybrid of Leu-enkephalin (Tyr-Gly-Gly-Phe-Leu) was prepared and its analgesic activity was examined. Poly(ethylene glycol) #4000 was converted to amino-poly(ethylene glycol) and coupled with the N^α-protected pentapeptide, followed by trifluoroacetic acid treatment to give the hybrid. The hybrid was soluble in water or various organic solvents. The analgesic activity of Leu-enkephalin was markedly potentiated by hybrid formation with poly(ethylene glycol).

• 社団法人日本薬学会の論文
• 1993-11-15

著者

• 真弓 忠範

  Faculty of Pharmaceutical Sciences

• 川崎 紘一

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• 前田 光子

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• 山城 祐子

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• 金戸 洋

  長崎大学薬学部薬物学教室

• 高橋 正克

  Faculty of Pharmaceutical Sciences, Nagasaki University

• 金戸 洋

  Faculty of Pharmaceutical Sciences, Nagasaki University

• 山城 祐子

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• 高橋 正克

  長崎大学薬学部医療情報・分析学教室

• 村上 智彦

  神戸学院大学 薬

• 山本 譲

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 前田 光子

  Life Science Center Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• 金戸 洋

  Faculty Of Pharmaceutical Sciences Nagasaki University 1-14 Bunkyocho Nagasaki

• Maeda M

  Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University:faculty Of Pharmac

• Yamamoto Y

  Tohoku Univ. Sendai Jpn

• Yamamoto Y

  Pharmaceutical Research Laboratory Hokuriku Seiyaku Co. Ltd.

• Yamamoto Y

  School Of Pharmaceutical Sciences Toho University

• Yamamoto Yoshio

  Pharmaceutical Research Division Takeda Chemical Industries Ltd.

• Yamamoto Y

  大阪薬科大学

• Kawasaki Keiko

  Biological Science Laboratories Kao Corporation

• 川崎 紘一

  Faculty Of Pharmaceutical Sciences & Cooperative Research Center Of Life Sciences Kobe Gakuin Un

• 山本 靖夫

  School Of Pharmaceutical Sciences Toho University

• Maeda Masatomo

  Laboratory Of Biochemistry And Molecular Biology Graduate School Of Pharmaceutical Sciences Osaka Un

関連論文

• VSVを利用した新規遺伝子導入ベクターの開発
• Studies on Ergothioneine. VIII. Preventive Effects of Ergothioneine on Cadmium-induced Teratogenesis
• Amino Acids and Peptides. XXVI. Laminin-Related Peptide Poly (Ethylene Glycol) Hybrids and Their Inhibitory Effect on Experimental Metastasis
• Amino Acids and Peptides. XXV. Preparation of Fibronectin-Related Peptide Poly(ethylene glycol) Hybrids and Their Inhibitory Effect on Experimental Metastasis
• Effect of a Monoclonal Anti-sperm Antibody (A-1) on in Vitro Fertilization in the Mouse
• Influence of Coenzyme Q_ on Doxorubicin Uptake and Metabolism by Mouse Myocardial Cells in Culture
• Evidence That Lipid Peroxidation by Doxorubicin Does Not Initiate the Beat Inhibition of Cultured Mouse Myocardial Cells(Pharmacological,Chemical)
• Effect of Adriamycin on Cultured Mouse Embryo Myocardial Cells(Pharmacological)
• Studies on Ergothioneine. XI. Inhibitory Effect on Lipid Peroxide Formation in Mouse Liver
• Studies on Ergothioneine. X. Effects of Ergothioneine on the Hepatic Drug Metabolizing Enzyme System and on Experimental Hepatic Injury in Rats
• Studies on Ergothioneine. VII. Some Effects of Ergothioneine on Glycolytic Metabolism in Red Blood Cells from Rats
• Studies on Ergothioneine. VI. Distribution and Fluctuations of Ergothioneine in Rats
• Quantitative Determination of Ergothioneine in Plasma and Tissues by TLC-Densitometry
• Studies on Ergothioneine. V. Determination by High Performance Liquid Chromatography and Application to Metabolic Research
• Amino Acids and Peptides. XXI. Laminin-Related Peptide Analogs Including Poly(Ethylene Glycol) Hybrids and Their Inhibitory Effect on Experimental Metastasis
• PREPARATION OF [ARG-GLY-ASP]-[AMINO-POLY(ETHYLENE GLYCOL)] HYBRIDS AND THEIR INHIBITORY EFFECT ON EXPERIMENTAL METASTASIS
• Reaction of Methyl 4,5-Epoxy-(2E)-pentenoate with Arenes. II. Application to the Synthesis of (±)-Curcudiol, (±)-Curcuphenol, (±)-Curcuhydroquinone, and (±)-Curcuquinone
• Reaction of Methyl 4,5-Epoxy-(2E)-pentenoate with Arenes. I. A Facile Synthesis of 4-Aryl-5-hydroxy-(2E)-pentenoate Derivatives
• CASTANEIOLIDE, ABSCISIC ACID AND MONORDEN, PHYTOTOXIC COMPOUNDS ISOLATED FROM FUNGI (MACROPHOMA CASTANEICOLA AND DIDYMOSPORIUM RADICICOLA) CAUSE "BLACK ROOT ROT DISEASE" IN CHESTNUT TREES
• フットショックストレス誘発鎮痛発現に及ぼすμオピオイド受容体 antisense oligodeoxynucleotide の影響
• 各種ストレス誘発鎮痛発現におよぼすμオピオイド受容体アンチセンスDNAの影響
• Amino Acids and Peptides. XXIV. Preparation and Antinociceptive Effect of [D-Ala^2,(N-Me)Phe^4]Enkephalin Analog-Poly(Ethylene Glycol)Hybrids
• Amino Acids and Peptides. XXIII. Leu-Enkephalin Analogs Containing a Fluorinated Amino Acid at Position 2,4 or 5
• Modulation of Morphine Action by Lauric Acid
• Human Chorionic Gonadotropin. VII. Preparation and Immunocharacteristics of Carboxyl-terminal Peptides of the β-Subunit of Human Chorionic Gonadotropin
• Human Chorionic Gonadotropin. VI. Synthesis of a Tetratriacontapeptide corresponding to the C-Terminal Sequence 112-145 of the β-Subunit of Human Chorionic Gonadotropin (hCG)
• Human Chorionic Gonadotropin. V. Synthesis of a Triacontapeptide corresponding to the C-Terminal Sequence 116-145 of the β-Subunit of Human Chorionic Gonadotropin (hCG)
• Human Chorionic Gonadotropin. IV. Synthesis of a Hexadecapeptide corresponding to the C-Terminal Sequence 130-145 of the β-Subunit of Human Chorionic Gonadotropin (hCG)
• Synthesis of C-Terminal Peptides of the β-Subunit of Human Chorionic Gonadotropin (hCG)
• 薬学部の医療薬学実習へのコミュニケーション技術教育の導入と学生による自己評価
• 抗不安薬のスクリーニング法(6) : 心理的ストレス反応を指標とした評価法
• Physical Dependence Produced by Dihydroetorphine in Mice
• Amino Acids and Peptides. XXII. Preparation and Antinociceptive Effect of [D-Ala^2] Leu-Enkephalin-Poly (Ethylene Glycol) Hybrid
• Amino Acids and Peptides. XIX. Preparation of Enkephalin-Poly(ethylene glycol) Hybrid and Evaluation of Its Analgesic Activity
• Antinociceptive Effect of Dihydroetorphine and Its Tolerance/Dependence Liability in Mice
• Isolation of Neoanisatin Derivatives from the Pericarps of Illicium majus with Other Constituents
• Sesquiterpene Lactofnes from the Pericarps of Illicium majus : 2-Oxy Derivatives of Neomajucin and 3,4-Dehydroxyneomajucin
• A NEW TOXIC NEOANISATIN DERIVATIVE FROM THE PERICARPS OF ILLICIUM MAJUS
• Isolation of Three New Sesquiterpene Lactones from the Pericarps of Illicium majus
• 〔5Met〕-と〔5Leu〕-enkephalinのラット脳粗シナプトゾ-ム(P2)画分からのIn vitro遊離--K+-刺激のCa2+-依存性と種々の薬物効果
• 鎮痛効果の測定法 (鎮痛剤)
• 依存性薬物の免疫学的定量法に関する最近の進歩
• 12-4-A3 長崎大学薬学部における医療薬学実習 : コミュニケーション技術実習の導入とその評価
• Amino Acids and Peptides. XVII. Synthesis of Peptides Related to N-Terminal Portion of Fibrin α-Chain and Their Inhibitory Effect on Fibrinogen : Thrombin Clotting
• Synthesis of a Tetradecapeptide corresponding to Sequence 90-103 of Bovine Adrenodoxin
• Amino Acids and Peptides. I. Synthesis of a Model Peptide related to Iron-Sulfur Protein
• Synthesis of Two Heptapeptides corresponding to Sequences 50-56 and 90-96 of Adrenodoxin from Bovine Adrenal Cortex and Formation of Their Iron-Sulfur Complexes
• Studies on Peptides. XVI. Regeneration of Lysine from N^ε-Formyllysine by Aqueous Hydrazine or Hydroxylamine and Their Application to the Synthesis of α-Melanocyte-stimulating Hormone
• Synthesis of a Tetradecapeptide corresponding to Sequence 50-63 of Adrenodoxin from Bovine Adrenal Cortex and Formation of Its Iron-Sulfur Complex
• Facile Conversions of Carboxylic Acids into Amides, Esters, and Thioesters Using 1,1'-Oxalyldiimidazole and 1,1'-Oxalyldi(1,2,4-triazole)(Organic,Chemical)
• Amino Acids and Peptides. X. : Leu-Enkephalin Analogues Containing a Fluorinated Aromatic Amino Acid
• Amino Acids and Peptides. IX. : Synthetic Studies on Leu-Enkephalin Analogues Containing a Ureylene Bond
• マウスを用いる回避学習モデルとプロリン特異性エンドペプチダ-ゼ阻害薬の抗健忘効果
• マウスにおけるプロリン特異性エンドペプチダ-ゼ阻害薬の抗健忘様効果
• 小動物を用いる薬物の精神的依存形成能の検定-3-マウスにおける依存性薬物溶液の選択摂取行動
• Amino Acids and Peptides. VII. : Preparation and Application of a Water-Soluble Active Ester, p-Trimethylammoniophenyl Ester
• Amino Acids and Peptides. VI. Synthesis of the N-Terminal Pentapeptide of α_2-Plasmin Inhibitor and Its Analogue
• Amino Acids and Peptides. IV. Synthesis and Analgesic Effects of Tyr-Containing Dipeptide Phenethylamides
• In Vivo Evaluation of Carborane Gadolinium-DTPA Complex as an MR Imaging Boron Carrier
• ストレス反応の病態生理学的解析と創薬
• Effect of Bredinin on Early Embryonic Development in Mice
• Synthesis and Biological Activity of Opioid Peptides Replaced Phenylalanine at Position 3 or 4 by 2, 6-Dimethylphenylalanine
• Biological Properties of Opioid Peptides Replacing Tyr at Position 1 by 2,6-Dimethyl-Tyr
• Amino Acids and Peptides. VIII. : A Water-Soluble Active Ester, Phenolsulfonic Acid Derivative(Organic,Chemical)
• The Effect of the Alkaline Earth Salts on the NMR Spectrum of Phenols
• The Use of Boron Trifluoride Etherate for Debenzyloxycarbonylation of Methionine-containing Peptides by Catalytic Hydrogenolysis
• Racemization Kinetics of Meluadrine Tartrate in Aqueous Solution
• Amino Acids and Peptides. XX. Preparation of β-Cyclododecyl Aspartate and Its Application to Synthesis of Fibronectin- and Laminin-Related Peptides
• No man is an island
• "薬"の本質と国家試験問題(薬剤師国家試験問題はこれでよいだろうか)
• 果たせなかった夢
• 生体防御機構としてのストレス誘発鎮痛
• Studies on Peptides. XXVIII. Synthesis of the Docosapeptide which Embodies the Entire Amino Acid Sequence of β-Melanocyte-stimulating Hormone from Human Pituitary Gland
• Characterization of the CYP2C8 Active Site by Homology Modeling
• Characterization of the CYP3A4 Active Site by Homology Modeling
• いたみと脳内オピオイドペプチド(慢性疼痛の心身医学第22回日本心身医学会総会シンポジウム)
• Mequitazine (10-(3-quinuclidinyl-methyl)-phenothiazine, LM-209)のバルビタール型身体的依存形成能に関する研究
• Studies on Quinolone Antibacterials. V. Synthesis and Antibacterial Activity of Chiral 5-Amino-7-(4-substituted-3-amino-1-pyrrolidinyl)-6-fluoro-1,4-dihydro-8-methyl-4-oxoquinoline-3-carboxylic Acids and Derivatives
• Studies on Quinolone Antibacterials. IV. Structure-Activity Relationships of Antibacterial Activity and Side Effects for 5- or 8-Substituted and 5,8-Disubstituted-7-(3-amino-1-pyrrolidinyl)-1-cycloporpyl-1,4-dihydro-4-oxoquinoline-3-carboxylic Acids
• A Comparison of Drug Transport through Cultured Monolayers of Bovine Brain Capillary and Bovine Aortic Endothelial Cells
• Conformation of 2-Aminomethylpyrrolidine and 2-Aminomethylpiperidine in Ternary Platinum (II) Complexes : Regulation of Conformation of the Diamine by the Coexisting Ligand
• Synthesis of Optically Active α-(p-Chlorophenyl)pyridylmethanols with Plant Cell Cultures
• Tetrabutylammonium Fluoride Promoted Regiospecific Reactions of Trimethylsilyl-o-Carborane with Aldehydes
• Effect of Inhibitor or Immobilization on Reduction of Benzoylpyridines by Baker's Yeast
• A New Water-soluble p-Boronophenylalanine Derivative for Neutron Capture Therapy
• Amino Acids and Peptides. XVI. Synthesis of N-Terminal Tetrapeptide Analogs of Fibrin α-Chain and Their Inhibitory Effects on Fibrinogen : Thrombin Clotting
• Amino Acids and Peptides. XIII. Synthetic Studies on N-Terminal Tripeptide Amide Analogs of Fibrin α-Chain
• Amino Acids and Peptides. V. Synthesis of Amino Acid Derivatives Containing a Sulfonamide Bond
• 依存性薬物の免疫学的定量法に関する最近の進歩
• Amino Acids and Peptides. III. Synthesis of Model Peptides Related to Cytochrome P-450
• 〔5Met〕-と〔5Leu〕-enkephalinのラット脳粗シナプトゾーム(P2)画分からのIn vitro遊離　K+-刺激のCa2+-依存性と種々の薬物効果
• マウスにおける脳虚血誘発健忘モデルの作製とこれに対する新規合成化合物の脳機能改善効果
• Guanabenz:[(2，6-Dichlorobenzylidene)amino]guanidine acetateのMorphine型およびBarbital型身体的依存形成能について
• 摘出モルモット回腸縦走筋標本におけるOpioidに対する耐性，依存の形成:その受容体モデルとしての有用性
• マウスにおけるプロリン特異性エンドペプチダーゼ阻害薬の抗健忘様効果
• マウスを用いる回避学習モデルとプロリン特異性エンドペプチダーゼ阻害薬の抗健忘効果
• 小動物を用いる薬物の精神的依存形成能の検定　3．マウスにおける依存性薬物溶液の選択摂取行動
• マウスを用いる向精神薬のBarbital型身体的依存性の検定
• Doxepinの耐性並びに身体的依存性形成能について
• Amino Acids and Peptides. XVIII. Synthetic Peptides Related to N-Terminal Portion of Fibrin α-Chain and Their Inhibitory Effect on Fibrinogen/Thrombin Clotting

もっと見る 閉じる

スポンサーリンク