In Vivo Evaluation of Carborane Gadolinium-DTPA Complex as an MR Imaging Boron Carrier

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概要

• 論文の詳細を見る

• The evaluation of the Gd-carborane complex 2 as an MR imaging and boron carrier agent was carried out in vivo using tumor-bearing Donryu rats, MRI, ICP-AES, and α-autoradiography. The MR imaging revealed that the carborane Gd-DTPA 2 was metabolized slower in the body than Gd-DTPA 1. The results of the ICP-AES method indicated that compound 2 was incorporated into normal tissues and metabolized quickly, whereas it was not accumulated into tumor or brain tissue. The α-autoradiography showed that a high level of boron was obtained in the internal organs and in the necrosis of tumor tissue.

• 公益社団法人日本薬学会の論文
• 2000-07-01

著者

• NAKAMURA Hiroyuki

  Department of Materials Science and Engineering, Kyoto University

• 山城 祐子

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• 根本 尚夫

  日本ゼオン株式会社総合開発センター

• Fukuda Hiroshi

  Department of Cardiology, Saiseikai Saijo Hospital

• 山本 譲

  Faculty Of Pharmaceutical Sciences Kanazawa University

• KOBAYASHI Tooru

  Research Reactor, Inst., Kyoto Univ.

• Yamamoto Y

  Tohoku Univ. Sendai Jpn

• Yamamoto Y

  Pharmaceutical Research Laboratory Hokuriku Seiyaku Co. Ltd.

• YAMAMOTO Yoshinori

  Department of Physics,Faculty of Science,Kobe University

• Yoshida Katsuya

  Division Of Advanced Technology For Medical Imaging Institute Of Radiological Sciences

• GIRALD Frank

  Division of Advanced Technology for Medical Imaging, Institute of Radiological Sciences

• AKAIZAWA Takashi

  Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer (IDAC), Toh

• NEMOTO Hisao

  Department of Chemistry, Graduate School of Science, Tohoku University

• CAI Jianping

  Department of Chemistry, Graduate School of Science, Tohoku University

• Yamamoto Y

  School Of Pharmaceutical Sciences Toho University

• Nemoto Hisao

  Department Of Chemistry Graduate School Of Science Tohoku University

• Cai Jianping

  Department Of Chemistry Graduate School Of Science Tohoku University

• Girald Frank

  Division Of Advanced Technology For Medical Imaging Institute Of Radiological Sciences

• Fukuda Hiroshi

  Department Of Nuclear Medicine And Radiology Institute Of Development Aging And Cancer (idac) Tohoku

• Fukuda Hiroshi

  Department Of Anatomy Kobe University School Of Medicine

• Nakamura Hiroyuki

  Department Of Dermatology Hokkaido University Graduate School Of Medicine

• Yamamoto Yoshio

  Pharmaceutical Research Division Takeda Chemical Industries Ltd.

• Yamamoto Y

  大阪薬科大学

• Akaizawa Takashi

  Department Of Nuclear Medicine And Radiology Institute Of Development Aging And Cancer (idac) Tohoku

• Hiratsuka Jun'ichi

  Department Of Radiology Kawasaki Medical School

• Kobayashi Tooru

  Research Reactor Institute Kyoto University

• Kobayashi Tooru

  Research Reactor Inst. Kyoto Univ.

• 山本 靖夫

  School Of Pharmaceutical Sciences Toho University

• Yamamoto Yoshinori

  Department Of Chemistry Faculty Of Science Tohoku University

• Nakamura Hiroyuki

  Department Of Chemistry Graduate School Of Science Tohoku University

• Nakamura Hiroyuki

  Department Of Biochemistry Osaka Medical Center For Cancer And Cardiovascular Diseases

• Nakamura Hiroyuki

  Department of Advanced Materials, University of Tokyo, Kashiwa, Chiba 277-8561

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