Conformation of 2-Aminomethylpyrrolidine and 2-Aminomethylpiperidine in Ternary Platinum (II) Complexes : Regulation of Conformation of the Diamine by the Coexisting Ligand

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Square-planar complexes with the formula [Pt (L_2) (L_1)] (X)_2・nH_2O, where L_1 is S-2-aminomethylpyrrolidine (S-pyrda) or 2-aminomethylpiperidine (pipda) and L_2 is diammine (X=Cl), cyclobutane-1, 1-dicarboxylato (cbdca) (X=none), 2, 2'-bipyridine (bpy) (X=NO_3), or 1, 10-phenanthroline (phen) (X=Cl), were prepared and the nature of the coordination of L_1 was examined by ^1H-NMR spectroscopy and X-ray crystallography. These 2-aminomethylazacycloalkane derivatives form five-membered chelate rings condensed with an azacycloalkane ring in cis- or trans-configurations. The ^1H-NMR spectrum of complexes with S-pyrda as L_1 were consistent with cis-condensed rings in an S (N) conformation with any of L_2 group. However, ^1H-NMR spectra of the complexes with pipda as L_1 indicated trans-fused successive rings for the diammine and cbdca as L_2, but spectra for bpy and phen as L_2 were consistent with a conformation having cis-fused successive rings. X-Ray crystallography data for the two complexes with pipda as L_1 and cbdca (1) and bpy (2) as L_2 confirms the different coordination behavior in the solid state.
公益社団法人日本薬学会の論文
2003-10-01